The response of the gut-brain axis to inflammation may be the basis of inflammatory bowel disease-related psychiatric symptoms

According to a new study, in order to deal with intestinal inflammation, such as inflammation caused by inflammatory bowel disease (IBD), the blood vessel barrier in the choroid plexus of the brain is closed, thereby locking the passage into the brain

Although this dysregulation of the intestinal cerebrovascular axis may protect the brain from inflammation, research results indicate that it may also cause various cognitive and psychiatric symptoms associated with IBD

Although the gut-brain axis is thought to be involved in driving these symptoms, the underlying mechanism remains unclear

According to the results of the study, the intestinal vascular barrier becomes more permeable due to the inflammatory process, allowing inflammation to spread outside the intestine

In a gene-driven mouse model of choroid plexus endothelial cell closure, Carloni et al.

DOI

10.

Article title

Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation