The results of the study were carried out on the NMD path of the fever-thymosiasis nematodes in primary animals.

The ubiquilime-mediated mRNA degradation path (Nonsense-mediated mRNA decay, NMD) is an important mRNA quality monitoring path in etonymutical biocells that identifies and degrades transcripts containing premature termination codons (PTC), thereby suppressing the potential damage to cells caused by the translation products of these abnormal mRNAs.
's study of the NMD path path path from single-cell yeast to multicellular flora and fauna shows that the composition factors of the NMD path path pathras of different species and the identification mechanism of PTC vary, so the study of the NMD path paths of model species in different evolutionary positions can help to understand the origin and evolution of the path.
The differentiation between native animal fibre caterpillars and widely used pattern species (yeast, worm, fruit fly, mouse, amoeba, etc.) and humans occurred in the early stages of the evolution of the posite, and the current lack of research on the NMD pathways of this group of organisms hinders a comprehensive understanding of the molecular mechanism of the NMD pathway and its origin and evolution.
The research team of Miao Wei, a researcher at the Institute of Aquatic Biology of the Chinese Academy of Sciences, studied the NMD pathway of the four membrane worms in combination with gene knock-out, immuno-precipitation and transcription group sequencing methods, and obtained the following main research results: 1) identified the four-film worm UPF1a, UPF2, UPF3 and SMG6L as the key factors of the NMD pathway. Wherein the SMG6L protein interacting with UPF1a is the nuclease specific to the main gate of the vesicle worm involved in degrading the PTC transcription; 2) it is determined that the identification of the NMD pathway of the four-film worm containing the PTC transcript does not depend on the exon-exon junction complex, EJC, and there is no interaction between the EJC composition factors of the diaphragm; 3) The 274 PTC mRNAs containing variable shears were identified and compared with the sequence structure of normal transcripts. The inclusions located downstream of the termination hypothetite are more likely to be the hallmarks of the four-film worm NMD path to identify the PTC transcript, so it is speculated that unknown factors involved in the inclusion of the subcutt may be involved in the process of identifying the PTC.
the findings have been published in Nucleic Acids Research.
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