The role of the Akt/mTOR signaling path in the side effect of non-dependent radiation in the nucleus.

Recently, the Radiation Biomedical Research Office of the Center for Medical Physics and Technology of the Hefei Institute of Material Sciences of the Chinese Academy of Sciences has made new progress in the side effects induced by cytoblast radiation.
research is published on Oncotarget (2017:8, 18010-18020) under the title Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.
long-term survivors of radiation therapy, the primary radiation outside the radiation area induces the occurrence of secondary cancer, which is the health enemy of the survivors.
radiation side effects are thought to be closely related to the occurrence of secondary cancer.
nucleosis and cytoste are important targets for radiation side effects.
, but for a long time, the relationship between the nucleuclee and the cytosygen has been inconsistencies in inducing radiation side effects.
radiation biologists speculate that cytosynthics need to pass through the nucleus to induce side effects, but this is difficult to prove due to the lack of experimental data.
whether the cytosygen can independently induce the radiation side effect depends on the function of the nucleuclea, which has been bothering the mechanism of radiation side effect.
researchers studied the cytoplasm processing of cell denuclearization and the side effects induced by cytoplasmic radiation.
results show that the precise radiation of cytoplasms (20 protons) with the help of a single beam radiation device can induce side effects, and there is no significant difference in the intensity of induced side effects compared to radiation (complete cell) cytoplasm.
20 proton radiation cytostes, which can cause the Akt/mTOR signaling path to activate quickly (10 minutes).
Akt-specific inhibitors (MK-2206) or mTOR-specific inhibitors pre-treatment revealed a correlation between cytosynthetic radiation side effects and Akt/mTOR signaling paths.
This study shows the presence of radiation side effects of non-dependent cell nuclear types, and expounds the role of Akt/mTOR signaling path in the radiation side effects of non-dependent cell nuclear types, which is of great significance for further exploring the cytoblast radiation side effects.
has been supported by projects such as the National Natural Science Foundation of China and the Project Cultivation Fund of hefei Material Science and Technology Center.
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