Calcium l-5-methyltetrahydrofolate ( calcium folinate ), also known as leucovorin, is a synthetic form of folic acid.
It is used in the chemical industry as an intermediate in the production of various pharmaceuticals and agrochemicals.
The safety of calcium folinate has been studied extensively, and it is generally considered to be safe when used as directed.
Calcium folinate has been classified as a Class 3 carcinogen by the International Agency for Research on Cancer ( IARC ), which means that it is not classified as probably carcinogenic to humans.
This classification is based on limited evidence of carcinogenicity in humans and insufficient evidence of carcinogenicity in animals.
However, it is important to note that this classification is based on limited evidence and more research is needed to fully understand the potential health effects of calcium folinate.
Inhalation exposure to high concentrations of calcium folinate vapor has been shown to cause irritation of the respiratory system in animal studies.
However, it is not known whether this would occur in humans.
There is limited information available on the potential health effects of long-term exposure to low levels of calcium folinate.
It is important to follow all safety precautions when handling calcium folinate, including wearing appropriate personal protective equipment and following proper handling and storage procedures.
It is also important to follow the instructions for use and any safety warnings provided by the manufacturer.
Overall, calcium folinate is generally considered to be safe when used as directed in the chemical industry.
However, it is important to be aware of the potential health effects and to take appropriate precautions when handling this substance.
Additional research is needed to fully understand the potential health effects of calcium folinate and to determine whether it is safe for long-term exposure.