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    Home > Medical News > Medical Science News > The selective recognition of kinin and its receptor activation molecular mechanism revealed

    The selective recognition of kinin and its receptor activation molecular mechanism revealed

    • Last Update: 2021-09-18
    • Source: Internet
    • Author: User
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    On September 9, researchers Jiang Yi, Xu Huaqiang, Wang Mingwei, associate researcher Yin Wanchao, and their collaborators at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences published their latest research results in Nature-Structure and Molecular Biology.


    10

    Kinin and its receptor are an important part of the kallikrein-kinin system (KKS)


    Although the amino acid sequence of each active kinin in the KKS system is similar, different kinins have obvious selectivity for B1R and B2R


    10

    In this study, the researchers used cryo-electron microscopy to analyze the three-dimensional structure of B1R and B2R combined with Des-Arg 10- kallidin and bradykinin and downstream Gq protein complexes, with a resolution of 3.


    10 10 3.


    This work was funded by the National Natural Science Foundation of China, the National Health Commission's major science and technology projects, the national key basic research plan, and the Shanghai major science and technology projects


    Related paper information: https://doi.


    https://doi.
    org/10.
    1038/s41594-021-00645-y
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