The shortage of cheap drugs has eased this year

this year, Shanghai, Shandong, Hunan, Guizhou and other places have issued beesterol, glycoside, methotrexate, glycerin nitrate, vitamin A acid and other drugs out of stock or insufficient supply of news. Recently, the supply of glyceal nitrate also caused the concern of Premier Li Keqiang of the State Council, admonished "to do a good job of commonly used drugs, first aid drugs to ensure stable prices, must not be out of stock, must not be wayetic price increases."The National Health and Safety Commission and other departments jointly issued a series of policies to address the shortage of drugs, targeted to solve the problem of drug supply. Recently, the Beijing News reporter visited a number of online and offline pharmacies found that the shortage of drugs has been alleviated, but there are still individual drugs in a state of cut-off, and there is no substitute.Raw material prices, such as nitrate glycerin out of stockthis year, nitrate glycerin cut off supply, price increases will be repeatedly reported, 100 pieces / bottle of nitrate glycerin tablets from 4 yuan to forty or fifty yuan, many pharmacies also appear out of stock situation, patients have to spend nearly 100 yuan to buy 25 tablets / bottle of imported drugs.At the end of April, the Beijing Municipal Drug Administration disclosed that the relevant departments and pharmacies have coordinated the purchase of nearly 600 drugstores in Beijing can buy nitrate glyceal tablets.However, the Beijing News reporter visited a number of physical pharmacies in Beijing on June 22 to learn that the supply of glyceal nitrate is still relatively tight, some pharmacies out of stock, some pharmacies are not many. Located in Yizhuang, Beijing Renkangtai big pharmacy Tongyu shop staff revealed that the shop is selling Beijing Yimin Pharmaceuticals nitrate glyceal, but currently out of stock, "when the delivery is uncertain, to how much is uncertain, generally only get a few bottles at a time, three bottles of eight bottles are possible, soon sold out, and sometimes even a person all bought." Pharmacies continue to ask manufacturers for goods, waiting for distribution. "Also Zhuang Libao Square Tongrentang pharmacy staff said, "there is only one box of glyceal nitrate left", each time only assigned to 10 boxes, will soon be sold out.Subsequently, the Beijing News reporter from 1 drug network, JD.com pharmacy platform of many drugstore flagship stores to see that nitrate glycerine basically have goods. Customer Service, the flagship store of Ren and Tondo Pharmacy, said that although it was in stock, inventory would change at any time.Since this year, the name of nitrate glyceal has also appeared frequently in Gansu, Ningxia, Shanghai, Guizhou, Shandong and other places related to drug shortage notice. For example, on April 26, Gansu Province's medicinal platform released 14 commonly used drugs to remove the network, because of the production line transformation, rising costs, shortage of raw materials, including the shortage of the drug nitroglycerin, glycosides and so on. The main reasons for the increase in the price of nitrate glyceal supply are the increase in raw material prices, the small number of manufacturers, and the tightening of environmental protection supervision leading to the closure and relocation of enterprises. Previously, the media had reported that Beijing Yimin Pharmaceuticals, Beijing Shunxin Xiangyun Pharmaceuticals two pharmaceutical companies because of the dismantling of equipment, exit Shunyi, the new plant is not put into use, drugs can not be produced. Hebei Medical University Pharmaceutical Factory and Shandong Xinyi Pharmaceuticals are due to the winter heating season environmental factors and raw materials purchase channels to tighten, resulting in a decline in production.Most of the shortage of drugs such as allopurinol tablets can not replacefrom this year's drug shortage information released throughout the country, in addition to glycerin nitrate, including glycoside, allopurinol, methotrexate, , filamentamycin and so on. On February 21st, Hunan Health and Safety Commission released a list of shortages of medicines in medical institutions for 2018, showing that 24 drugs, including methotrexate and allopurinol tablets, are not irreplaceable. As of February this year, six of the drugs that are not available have been restored to supply.Such as injection of fissamycin, which had previously been cut off for 18 months, in the National Health And Safety Commission, the State Drug Administration and other multi-sectoral support, Hanyu Pharmaceutical investment of tens of millions of yuan to develop reagents, submit applications, and through the rapid approval of the green channel to complete all pre-market approval procedures, in August 2018 listed supply, the price is also higher than before. However, the name of fissamycin appeared in this year's Guizhou, Shandong issued a shortage of drugs announcement.Another blood tumor treatment drug injection agasin, due to Pfizer announced in early January this year, the Italian-based manufacturer shut down maintenance, its production of a glycosin injection sterile powder (the commodity name "Sidesa") will be in short supply in some markets worldwide from January 2019, initially expected Sedesa will gradually resume supply after July this year. Pfizer accounts for more than 97 percent of the overall agarose glycoside market, according to the Comprehensive Drug Database (PDB).According to the information of the State Drug Administration, there are 4 domestic production enterprises of the raw material drug acrylic hydrochloride, including Haizheng Pharmaceuticals, Lingnan Pharmaceuticals, Leibotong Pharmaceuticals, Slimin Pharmaceuticals, 11 approvals for injection of acetic glycosides hydrochloride, belonging to Chenxin Pharmaceuticals, Furen Pharmaceuticals, Hanyu Pharmaceuticals, National Pharmaceuticals, etc.After Pfizer's announcement, the National Health And Wellness Commission's Department of Medicine and Administration on January 7 issued a "notice on doing a good job in the supply of glycosin injections to ensure the work", said that the national shortage of drug supply guarantee mechanism office and the domestic current production of two enterprises to communicate, will fully maintain the market supply. China National Pharmaceuticals began expanding production capacity in January to focus on the supply market. Hanyu Pharmaceuticals also guarantees that the existing supply will not be interrupted.However, as originally expected, agarose is still facing a tight supply situation. In the second batch of shortage drugs released by Guizhou Province on June 20th, a glycosine was listed.ExpertsCracking the shortage of cheap drugs still needs "new prescriptions Since 2018, the National Health and Safety Commission, in cooperation with other departments, has taken a series of policy measures to conduct joint sectoral research on drug shortages, price increases and monopolies Drug discontinuation reporting system, strengthen monitoring and early warning and classification response, form a list of vulnerable drugs that require national attention, promote the centralized production and reserve of shortage drugs, combat illegal and illegal activities, and continuously strengthen price supervision in the field of medicine, so as to solve the supply of more than 100 kinds of drugs such as fish protein, -yuan, etc. 　　On June 20, the National Health and Safety Commission announced the first batch of recommendations to encourage generic drugs, and 34 drugs contained shortages of drugs jaundice, methotrexate tablets and so on. 　　Zeng Yixin, deputy director of the National Health and Health Commission, has pointed out that the National Health and Health Commission will continue to play the role of the mechanism of the association of shortage drug supply guarantee, and promote the establishment of a shortage of drug supply guarantee system. We should not only monitor and warn of shortages, but also establish a list, increase the effective supply of medicinal raw materials, promote market matchmaking and the construction of a centralized production base for small varieties, and achieve a stable production and supply of 100 small varieties of drugs by 2020. To investigate and combat some hoarding, monopoly of supply, deliberately raise market prices, improve drug procurement policies and reserve mechanisms. Finally, we should further improve the research and development capability and imitation production capacity of drugs, form a shortage of drug supply guarantee system, fundamentally solve the problem of drug shortage. 　　"Now the tender price of cheap drugs, base drugs is less than two or three years, or even four or five years to make an adjustment, and environmental monitoring factors, api monopoly and other factors led to the rise in drug costs, the original tender price does not apply, hospital usage can not be guaranteed, pharmaceutical companies do not want to lose money to dry, so cut off supply, waste of tender incidents frequently." Shi Lichen, founder of Beijing Dingchen Pharmaceutical Management Consulting Company, believes that in order to completely solve the shortage of cheap drugs and base drugs, it is possible to purchase drugs in accordance with the "4 plus 7" pilot city drug collection method, which is unified by the Medical Insurance Bureau. At the same time monitor the hospital inventory situation, to prevent the clear storage of drugs but doctors do not love to open low-cost drugs caused by human factors "cut off supply" phenomenon of drugs. (New Beijing News)