The story of Coley's Toxins

Corey Toxin

William Coley (W.

Unfortunately, this therapy failed to pass GMP production standards and modern clinical trials in time and was listed as an unproven therapy by the FDA in 1963.

Drug source analysis

Corey is an orthopedic surgeon who works at Memorial Hospital in New York.

The first patient to use this therapy started taking the drug in May 1891 and relapsed after several months of continuous use.

Cory obviously couldn't find antibiotics himself, so he started to use heat to inactivate streptococci, but the effect was very poor.

Other doctors also tried to use this therapy, but because there is no modern GMP production process, the activity of each company is different, so the efficacy is not consistent.

In recent years, some manufacturers have tried to redevelop this toxin with modern pharmaceutical technology, but it is difficult to pass ethics because of the need to induce a rise in body temperature.

This wonderful therapy, which is considered to be the originator of immunotherapy, also gives us some useful enlightenment.

As early as the 18th century, there were reports of tumor disappearance caused by infection, of which two cases were more prominent.

This story also shows that technology and knowledge limitations are not decisive for the discovery of new drugs.

Although someone later saw the immune activation and tumor control activity of Corey toxin in the current mouse model, there was no such model at that time.