The study found that the new subsurfic type of nicotine alkaloid

Recently, Aji Aikbair Issa, a researcher in the national drug research and innovation team at the Xinjiang Institute of Science and Technology of the Chinese Academy of Sciences, found seven new compounds (1-7) in the whole grass distributed in Xinjiang.
, the compound Barpuberudine (1) is the new skeleton type C20-dyrene alkaloid, the compounds Barpubenines A(6) and B (7) are rear-rowed C18-dyrene alkaloids.
through HR-ESI-MS, 1D and 2D NMR and other spectral data analysis, the plane structure and relative configuration of the new compound 1-7 are determined, compound 1 is a C20-dyr alkaloid with a novel skeleton, and the source is presumed to be The pathway is that the compound Barpuberudine D(4) as a preposition compound, by the C-11 and C-12 bonds of the fractured opening ring and C-9 bit isomerization, and then by atomization and O-methylation to obtain 1 (Figure 2).
screening of new compounds 1-7 for cytotoxicity of A-549 and Hela 2 cancer cell strains, the results showed that no significant cytotoxicity was shown in all compounds (IC50-gt;50μM); The antibacterial activity of E. coli (ATCC 11229) and Staphylococcus acolytic (ATCC 6538) showed that compounds 1, 4 and 7 had different degrees of antibacterial activity against Staphylococcus acuity, and compound 4 had some antibacterial activity against white Candide.
the study enriches the chemical structural diversity of nicotine alkaloids and lays the foundation for further development and utilization of the plant resources of The Utou genus, which has xinjiang characteristics.
Diterpenoid alkaloids are a complex and active class of nitrogen-containing organic compounds derived mainly from the Aconitum and Delphinium plants of ranunculeceae
Because of its variety, wide source, complex and variable structure, and generally has the characteristics of both active and toxic, so that the alkaloid is not only the current hot spot of plant chemistry research, but also the breakthrough point of pharmaceutical chemistry research and development of new drugs.
foundalkaloids found in the genus mascarpone in the genus mascarpone have the effects of analgesic, anti-inflammatory, hemp and strong heart.
used to treat chronic bronchitis, lower back and leg pain, joint swelling pain, external treatment of ricky palate, lymph nodes and so on.
Phytochemistry, PhD student Nurpida Abrajiang is the first author of the paper and Aji Iqbayr Issa is the paper's correspondent.
was supported by the Xinjiang Uygur Autonomous Region International Science and Technology Cooperation Project, the Chinese Academy of Sciences International Cooperation Project and the Central Asian Drug Research and Development Center of the Chinese Academy of Sciences.
()