The study revealed a new mechanism for abnormal active B cells of primary drying syndrome

Recently, Zhang Fengchun, a professor in the department of rheumatology immunology at Concord Hospital in Beijing, led a team of researchers who explored the gene expression spectrum of primary drying syndrome (pSS) B cells, found the expression of endotyl substitia interaction protein 1 (EPSTI1), and revealed for the first time the mechanism by which the protein regulates abnormal activity of B cells. The findings were published in the Rheumatology Yearbook.
pSS is one of the common rheumatism diseases, the prevalence rate as high as 0.29% to 0.77%, clinical manifestations are diverse, light patients only dry mouth, dry eyes, serious cases of tired kidneys, liver, lungs and other important organs, and may even lead to death.
pathogenesis of pSS is complex and not yet fully clear. B-cell abnormalization is one of its main immunological abnormalities, in order to explore its mechanism, the team from high-volume sequencing, analysis of pSS B cell transcription group abnormalities; EPSTI1, confirmed that EPSTI1 is highly expressed in pSS epithrea and lip tissue B cells, and then found that EPSTI1 regulates the proliferation of B cells, and analyzes the molecular mechanism of EPSTI1 regulating B cell activity. Finally, the study found that the new mechanism of B cell regulation and the new mechanism of abnormal active B cells of pSS, and pointed out the potential of EPSTI1 as a therapeutic target.
Zhang Fengchun introduced, primary dryness syndrome has two immunological characteristics: first, the production of autoantibodies such as anti-SSA antibodies, anti-SSB antibodies, etc. ; Excessive elevation of globulins indicates abnormal immune activity in the body and can lead to damage to the body.
according to information provided by Beijing Concord Hospital, pSS patients have a 48.1 times higher risk of developing lymphoma than normal people, and those with high globulinemia have a higher risk of developing lymphoma.
could be translated into new treatments to improve conditions in pSS patients and prevent related complications such as lymphoma, the researchers said.
" clinicians have their own special advantages in doing research. Zhang Fengchun said that in clinical work, doctors can find some textbooks unexplained or only the phenomenon did not find the cause of the disease and symptoms, these can be translated into scientific research problems for further study and solution. For example, pSS may seem like a disease, but it actually contains a lot of complex problems. If it is likened to the root of a tree, branches will appear dry mouth, dry eyes, heart damage, lung damage, kidney damage, liver damage and other different clinical manifestations, pSS patients are also easy to merge rheumatoid arthritis, primary bileitis and other diseases, autoimmune diseases are usually a combination of multiple genetic abnormalities to determine genetic susceptivity, pSS still has many pathogenic genes to be found, many mechanisms to be clarified. (Source: Zhang Siwei, China Science Journal)
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