The study revealed the molecular mechanism of microorganisms affecting the effects of chemotherapy in colorectal cancer patients

With funding from the National Natural Science Foundation of China," fang Jingyuan, a professor at Renji Hospital affiliated with Shanghai Jiaotong University School of Medicine, and Weiping Zou, a professor at the University of Michigan in the United States, revealed for the first time that a significant increase in intestinal tract abundance in patients with relapse colorectal cancer was an important factor in the failure of chemotherapy in 5-FU (5-fluoruriacine) and Osali platinum, and expounded the molecular mechanisms that cause chemotherapy resistance, the study was published on
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the relationship between intestinal bacteria disorder and the development of colorectal cancer is attracting more and more attention, however, whether the change of enterobacteria affects the effect of chemotherapy for colorectal cancer is not clear. Ocytobacteria is a kind of spore-free anaerobic bacteria widely found in the human body and a variety of animals, has been regarded as one of the normal bacteria in the human body, especially in the mouth and pharynx, but rarely in the mucosa of normal human intestines.
The study looked at patients who relapsed and did not relapse after chemotherapy for colorectal cancer (including 5-FU and Osali platinum), and through DNA sequencing analysis of the intestinal mucosa in patients, it was found that the abundance of intestinal tract tract in relapsed patients increased significantly; From the cell model, animal experiments and clinical population cohort, the study first revealed the effect of OCS on the efficacy of chemotherapy in colorectal cancer, and explained the molecular mechanism of chemotherapy resistance caused by Ocadorobacteria, which provided new methods for predicting the effect of chemotherapy for colorectal cancer clinically, judging prognosis, and provided new ideas for improving the therapeutic effect of colorectal cancer