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    Home > Biochemistry News > Microbiology News > The success of weight loss is closely related to your intestinal flora!

    The success of weight loss is closely related to your intestinal flora!

    • Last Update: 2021-10-01
    • Source: Internet
    • Author: User
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    Recently, I always hear a lot of people complain: "Why I shut my mouth and opened my legs, but the weight is still stable like Mount Tai
    .

    " This must be related to your gut microbiome
    .

    As we all know, the intestinal microbiome (ie, intestinal flora) is closely related to human health and diseases, such as obesity, cardiovascular disease, type 2 diabetes, cancer, and mental illnesses such as depression and Alzheimer's
    .

    Previously, a large number of studies have confirmed that the composition of intestinal flora varies from person to person, and that healthy people have great similarities; unhealthy people show great differences in bacterial composition
    .

    The composition and diversity of the intestinal flora are also related to body mass index (BMI) and metabolic health markers, and have been shown to regulate animal body weight
    .

    Recent human experiments have also shown that the baseline composition of the intestinal flora can determine the individual’s response to weight loss interventions
    .

    In other words, the success of weight loss depends on your intestinal flora
    .

    However, the functional determinants behind this phenomenon are still elusive
    .

    Some studies believe that the ecological composition of the intestinal flora has a causal effect on the results of weight loss
    .

    However, this statement is still controversial
    .

    In a new study published in the journal "mSystems" under the American Society for Microbiology on September 15, Beijing time, a research team from the University of Washington and the Institute of Systems Biology (ISB) added new ideas to this controversial statement.
    Evidence
    .

    The study found that a person's intestinal flora does affect their weight loss success rate, and this has nothing to do with BMI
    .

    The research also opens the door to diagnostic testing, which is expected to identify individuals who can successfully lose weight due to changes in healthy life>
    .

    The research also opened up a new way for the development of weight-loss products based on intestinal flora
    .

    In this study, the researchers surveyed 105 participants who participated in a diet plan.
    They all participated in a commercial health program that included healthy life>
    .

    Each participant in the cohort has baseline blood metabolomics, blood proteomics, clinical data, diet questionnaires, fecal 16S rRNA gene sequencing data, and follow-up data on weight changes
    .

    Approximately half (48 people) of the participants showed sustained weight loss and improvements in metabolic health indicators; while the other half (57 people) did not respond to the intervention and maintained a stable weight
    .

    Researchers have found that the intestinal flora of those who have succeeded in losing weight has a higher rate of bacterial growth and is rich in genes that transfer dietary nutrients to bacterial cell growth
    .

    On the contrary, those who are ineffective for weight loss have a lower bacterial growth rate in the intestinal flora, but have a higher ability to break down non-absorbable fiber and starch into absorbable sugars
    .

    Moreover, their intestinal flora is also prepared for the intestinal inflammatory environment
    .

    Researchers believe that the acquisition of dietary energy, host-microbial competition, and the regulation of inflammation by symbiotic bacteria may determine the host's response to weight loss intervention to a certain extent, which does not depend on baseline BMI or metabolic health
    .

    The metabolically optimized intestinal ecosystem and higher bacterial growth rate seem to be more conducive to weight loss
    .

    Previous studies have shown that a higher baseline level of Prevotella can improve the weight loss response to a standardized high-fiber diet
    .

    In this study, the researchers also found that in individuals who succeeded in losing weight, the baseline bacterial growth rate was higher, partly driven by Prevotella
    .

    Prevotella and other Bacteroides seem to be more effective in using the degradation products of complex starch and fiber to promote growth and reduce the amount of calories from food
    .

    Researchers say that ensuring that gut microbes can effectively convert sugars isolated from dietary fiber into short-chain fatty acids and/or reduce the abundance of bacterial fiber degradation genes in the intestine will help improve weight loss through healthy life>
    .

    The corresponding author of the study and Dr.
    Sean Gibbons, assistant professor at ISB, concluded: "Our work may lead to new diagnostic methods to determine who responds well to changes in healthy life>
    .

    By understanding which microbes and metabolic processes help promote gut microbiota-driven weight loss, we can begin to design targeted probiotics and prebiotic interventions to turn those gut microbiomes that fight weight loss into The microbiome is more conducive to weight loss
    .

    "The link to the paper: https://journals.
    asm.
    org/doi/epub/10.
    1128/mSystems.
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