The Synthetic Routes of 2-(6-Chloro-pyridazin-3-yloxy)-quinoxaline, 98+% C12H7ClN4O, MW: 258.67

2-(6-Chloro-pyridazin-3-yloxy)-quinoxaline is an important organic compound that is widely used in the chemical industry.
This compound is synthesized through various routes, each with its own set of advantages and disadvantages.
In this article, we will discuss the synthetic routes of 2-(6-Chloro-pyridazin-3-yloxy)-quinoxaline, including the conventional routes as well as the more recent developments in the field.

Conventional Synthetic Routes of 2-(6-Chloro-pyridazin-3-yloxy)-quinoxaline

The conventional synthetic routes of 2-(6-Chloro-pyridazin-3-yloxy)-quinoxaline typically involve several reaction steps, each of which requires careful optimization of reaction conditions to achieve the desired yield.
One of the most common routes involves the following steps:

1. Synthesis of 2-chloropyridazine: This involves the reaction of pyridine with chloroform under appropriate reaction conditions to yield 2-chloropyridazine.
   
2. Synthesis of 3-iodoquinoline: This involves the reaction of 2-chloropyridazine with iodine in the presence of a solvent, such as acetone or ether, to yield 3-iodoquinoline.
   
3. Synthesis of quinoxaline-2,3-dione: This involves the reaction of 3-iodoquinoline with formaldehyde in the presence of an acid catalyst, such as sulfuric acid, to yield quinoxaline-2,3-dione.
   
4. Synthesis of 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline: This involves the reaction of quinoxaline-2,3-dione with 6-chloropyridine in the presence of a solvent, such as acetonitrile or DMF, and a catalyst, such as triethylamine, to yield 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline.
   

Recent Synthetic Routes of 2-(6-Chloro-pyridazin-3-yloxy)-quinoxaline

In recent years, chemists have developed new and more efficient synthetic routes for 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline, which offer several advantages over the conventional routes.
Some of the recent developments in the field include:

1. One-pot synthesis of 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline: This involves the synthesis of 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline in a single pot through the reaction of 2-chloropyridazine with 6-chloropyridine in the presence of a catalyst, such as sodium hydroxide, and a solvent, such as water or dioxane.
   
2. Microwave-assisted synthesis of 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline: This involves the use of microwave irradiation to speed up the reaction between 2-chloropyridazine and 6-chloropyridine in the presence of a solvent, such as THF, and a catalyst, such as cesium carbonate.
   
3. Solvent-free synthesis of 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline: This involves the synthesis of 2-(6-chloro-pyridazin-3-yloxy)-quinoxaline in the absence of a solvent