The Synthetic Routes of 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE

The synthetic routes of 2-benzyl-4,5-dichloro-2,3-dihydropyridazine-3-one, commonly referred to as 2,3-Dichloro-5,6-dimethyl-4-(2-benzyl)-1,2,3,4-tetrahydro-pyridazine-sulfonamide, are numerous and diverse, with various methods and techniques used to synthesize this complex organic compound.

One synthetic route involves the condensation of 2-benzyl-4,5-dichloro-2,3-dihydro-pyridazine-3-one with 5,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-4-sulfonyl chloride in the presence of an appropriate solvent, such as dichloromethane or chloroform.
The reaction is typically carried out under anhydrous conditions and with the use of an appropriate base, such as triethylamine or pyridine.
The resulting product can then be purified using standard techniques, such as chromatography or crystallization, to yield the desired compound.

Another synthetic route involves the reduction of 5,6-dimethyl-2-oxo-[1,2,3,4]tetrahydro-pyrimidine-4-sulfonic acid with a reducing agent, such as lithium aluminum hydride or hydrogen in the presence of a polar protic solvent, such as water or acetone.
The resulting product can then be converted to the desired compound through a variety of methods, such as the nucleophilic substitution of the chloride group with a benzyl halide or the condensation of the reduced sulfonamide with a benzyl halide.

A third synthetic route involves the condensation of 2-benzyl-4,5-dichloro-pyridine-3,5-diamine with 5,6-dimethyl-1,2,3,4-tetrahydro-pyrimidine-4-sulfonyl chloride in the presence of an appropriate solvent, such as dichloromethane or chloroform.
The reaction is typically carried out under anhydrous conditions and with the use of an appropriate base, such as triethylamine or pyridine.
The resulting product can then be purified using standard techniques, such as chromatography or crystallization, to yield the desired compound.

In all of these synthetic routes, the starting materials and reagents must be handled carefully and with appropriate safety precautions, as they may be hazardous or unstable.
The reaction conditions must also be carefully controlled and monitored to ensure the safety of the process and the yield and purity of the desired product.

In conclusion, the synthetic routes of 2-benzyl-4,5-dichloro-2,3-dihydro-pyridazine-3-one are diverse and can involve a variety of reactions and techniques, depending on the specific starting materials and desired product.
The synthesis of this complex organic compound requires careful handling and monitoring of hazardous reagents and conditions, and is typically carried out in a well-equipped laboratory setting.