The Synthetic Routes of 2-(Methylthio)-4-(trifluoromethyl)pyrimidine

2-(Methylthio)-4-(trifluoromethyl)pyrimidine is a synthetic compound that is commonly used in the chemical industry for various applications.
This article will discuss the synthetic routes of 2-(methylthio)-4-(trifluoromethyl)pyrimidine, which can be broadly classified into three categories based on the starting materials and the synthesis method.

1. Synthesis from N-methylthiophenamide and N-fluorodiaminopyrimidine

One of the commonly used methods for synthesizing 2-(methylthio)-4-(trifluoromethyl)pyrimidine is by reacting N-methylthiophenamide and N-fluorodiaminopyrimidine.
To synthesize this compound, N-methylthiophenamide is first synthesized by reacting methyl isothiocyanate and ammonia in the presence of a base such as sodium hydroxide.
N-fluorodiaminopyrimidine is then synthesized by reacting dichloroacetic acid and hydrogen fluoride in the presence of a solid base such as sodium hydroxide or potassium hydroxide.

The reaction between N-methylthiophenamide and N-fluorodiaminopyrimidine is carried out in a suitable solvent such as alcohol or ether.
The reaction is typically carried out at room temperature and is often complete within a few hours.
The product can then be purified by crystallization or by using a solid phase extraction column.

1. Synthesis from Methyl Iodide and N-Fluoropyrimidine

Another method for synthesizing 2-(methylthio)-4-(trifluoromethyl)pyrimidine involves the reaction of methyl iodide and N-fluoropyrimidine.
To synthesize this compound, methyl iodide is first synthesized by reacting iodine and methyl alcohol in the presence of a solvent such as acetone or ethyl acetate.
N-fluoropyrimidine is then synthesized by reacting chloroacetamide and hydrogen fluoride in the presence of a catalyst such as zinc chloride or aluminum chloride.

The reaction between methyl iodide and N-fluoropyrimidine is carried out in a suitable solvent such as acetonitrile or DMF.
The reaction is typically carried out at a higher temperature, such as 80-100°C, and is often complete within a few hours.
The product can then be purified by crystallization or by using a solid phase extraction column.

1. Synthesis from Ammonia and 4-Chloro-3-nitrophenylamine

2-(Methylthio)-4-(trifluoromethyl)pyrimidine can also be synthesized by reacting ammonia and 4-chloro-3-nitrophenylamine.
To synthesize this compound, 4-chloro-3-nitrophenylamine is first synthesized by reacting 4-chloro-3-nitroaniline with ammonia in the presence of a solvent such as water or methanol.
The reaction is typically carried out at a higher temperature, such as 100-120°C, and is often complete within a few hours.

The reaction between ammonia and 4-chloro-3-nitrophenylamine is carried out in a suitable solvent such as methanol or ethanol.
The reaction is typically carried out at a lower temperature, such as 50-60°C, and is often complete within a few