The Synthetic Routes of 2-PIPERAZINONICOTINONITRILE

2-Piperazinonitrile is an organic compound that is commonly used in the chemical industry as a building block for the synthesis of various chemicals, pharmaceuticals, and agrochemicals.
The synthesis of 2-piperazinonitrile can be achieved through several methods, and in this article, we will explore some of the most widely used synthetic routes for this compound.

One of the most common methods for the synthesis of 2-piperazinonitrile involves the reaction of acetamide with chloroform in the presence of a strong acid catalyst, such as sulfuric acid.
This reaction leads to the formation of N-acetyl-N-(2-hydroxyethyl) piperazine, which can then be reduced to 2-piperazinonitrile using a reducing agent such as lithium aluminum hydride (LiAlH4).

Another synthetic route for 2-piperazinonitrile involves the reaction of chloroacetamide with ammonia in the presence of a base such as sodium hydroxide.
This reaction leads to the formation of N-(2-chloroacetyl)piperazine, which can then be dehydrogenated to 2-piperazinonitrile using a dehydrogenation catalyst such as platinum oxide.

2-Piperazinonitrile can also be synthesized by the reaction of 2-aminopropanamide with chloroform in the presence of a strong acid catalyst, such as sulfuric acid.
This reaction leads to the formation of N-chloro-N-methyl piperazine, which can then be reduced to 2-piperazinonitrile using a reducing agent such as sodium borohydride.

Another synthetic route for 2-piperazinonitrile involves the reaction of dimethylformamide with chloroform in the presence of a strong acid catalyst, such as sulfuric acid.
This reaction leads to the formation of N-methyl-N-(2-chloroethyl) piperazine, which can then be reduced to 2-piperazinonitrile using a reducing agent such as lithium aluminum hydride.

In addition to the above-mentioned synthetic routes, 2-piperazinonitrile can also be synthesized by the reaction of N-phenylpiperazine with chloroform in the presence of a strong acid catalyst, such as sulfuric acid.
This reaction leads to the formation of N-phenyl-N-(2-chloroethyl) piperazine, which can then be reduced to 2-piperazinonitrile using a reducing agent such as sodium borohydride.

It is worth noting that the selection of the synthetic route for 2-piperazinonitrile will depend on a variety of factors, including the availability and cost of the starting materials, the desired yield and purity of the product, and the intended end use of the compound.
In addition, the synthetic routes described above may require modifications or adjustments depending on the specific conditions and reagents used.

Overall, the synthetic routes for 2-piperazinonitrile are numerous and varied, and offer a range of options for the chemical industry.
Whether used as a building block for the synthesis of other chemicals or as an intermediate in the production of pharmaceuticals or agrochemicals, 2-piperazinonitrile is an important compound with a wide range of applications in the chemical industry.