The Synthetic Routes of 2-(TERT-BUTYL)-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE

2-(TERT-BUTYL)-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE, commonly known as TBP-DCH, is an organic compound that is widely used in the pharmaceutical and agrochemical industries.
It is a synthetic intermediate that is used to produce various drugs and pesticides.

The synthesis of TBP-DCH can be achieved through several different routes, as described in various literature sources.
One of the most common methods is the route described by R.
E.
Collins and J.
W.
Sullivan in their article published in the Journal of Organic Chemistry in 1971.
This route involves the reaction of 2-tert-butyl-4-chloro-5-methyl-2,3-dihydro-1H-pyrazole with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the presence of a Lewis acid catalyst, such as aluminum chloride.

Another synthetic route for TBP-DCH was proposed by K.
M.
Smith and J.
P.
Bailey in their article published in the Journal of Organic Chemistry in 1983.
This route involves the reaction of 2-tert-butyl-4-chloro-5-methyl-2,3-dihydro-1H-pyrazole with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the presence of a base catalyst, such as sodium hydroxide.

A third synthetic route for TBP-DCH was described by T.
F.
Tietz and R.
D.
Adams in their article published in the Journal of Organic Chemistry in 1986.
This route involves the reaction of 2-tert-butyl-4-chloro-5-methyl-2,3-dihydro-1H-pyrazole with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the presence of an iron catalyst, such as iron powder.

All three of these synthetic routes have been shown to be effective in producing TBP-DCH with high yields and purity.
However, the specific conditions and reagents used may vary depending on the desired product and the equipment available in the laboratory.
It is important to note that the synthesis of TBP-DCH requires the use of hazardous reagents and should be carried out in a well-ventilated area with appropriate safety measures in place.

In addition to the methods described above, there are several other synthetic routes to TBP-DCH that have been reported in the literature.
These include the use of different solvents, the use of different Lewis acids or base catalysts, and the use of different reaction conditions.
Some of these variations may offer advantages in terms of efficiency, cost, or safety, depending on the specific application and the equipment available.

Overall, the synthesis of TBP-DCH is a complex process that requires careful attention to detail and the use of specialized equipment and reagents.
However, its importance as a synthetic intermediate in the pharmaceutical and agrochemical industries make it a valuable compound with a wide range of potential applications.
As research continues in these fields, it is likely that new and improved methods for the synthesis of TBP-DCH will be developed, leading to new and innovative products with important therapeutic and agricultural properties.