The Synthetic Routes of 3-AMINO-N-BENZYLBENZENESULFONAMIDE

3-Amino-N-benzylbenzenesulfonamide is a derivative of benzenesulfonic acid and aminobenzene.
It is a white to off-white solid that is soluble in water and organic solvents.
This compound is commonly used as a catalyst in chemical reactions and as a ligand in metal complexes.
It is also used in the production of certain pharmaceuticals and agrochemicals.

There are several synthetic routes that can be used to synthesize 3-amino-N-benzylbenzenesulfonamide.
The following are some of the most common methods:

1. Direct Nitration of Benzene

The most straightforward method of synthesizing 3-amino-N-benzylbenzenesulfonamide is by direct nitration of benzene with nitric acid.
The reaction involves the addition of nitric acid to benzene, which leads to the formation of nitrobenzene.
The nitrobenzene is then treated with sodium hydroxide to convert it to the corresponding amine.
This amine is then treated with benzenesulfonic acid to form the desired sulfonamide.

2. Nitration of Benzaldehyde

Another method of synthesizing 3-amino-N-benzylbenzenesulfonamide is by nitration of benzaldehyde with nitric acid.
The reaction involves the addition of nitric acid to benzaldehyde, which leads to the formation of nitrobenzaldehyde.
The nitrobenzaldehyde is then treated with sodium hydroxide to convert it to the corresponding amine.
This amine is then treated with benzenesulfonic acid and anhydrous potassium carbonate to form the desired sulfonamide.

3. Nitration of Benzyl Chloride

3-amino-N-benzylbenzenesulfonamide can also be synthesized by nitration of benzyl chloride with nitric acid.
The reaction involves the addition of nitric acid to benzyl chloride, which leads to the formation of nitrobenzyl chloride.
The nitrobenzyl chloride is then treated with sodium hydroxide to convert it to the corresponding amine.
This amine is then treated with benzenesulfonic acid and anhydrous potassium carbonate to form the desired sulfonamide.

4. Reduction of Nitrobenzene

3-amino-N-benzylbenzenesulfonamide can also be synthesized by reducing nitrobenzene with hydrogen in the presence of a catalyst, such as palladium on barium sulfate.
The reaction involves the addition of hydrogen to nitrobenzene, which leads to the formation of aminobenzene.
The aminobenzene is then treated with benzenesulfonic acid to form the desired sulfonamide.

In conclusion, there are several synthetic routes that can be used to synthesize 3-amino-N-benzylbenzenesulfonamide.
The choice of synthesis route depends on the availability of starting materials and the desired yield and purity of the final product.
The synthesis of this compound is important in the production of certain pharmaceuticals and agrochemicals, and it has applications in the field of organic synthesis as a catalyst and ligand.