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3-Chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride is an organic compound that is commonly used in various chemical reactions in the industry.
It is a white or almost white crystalline powder with a molecular weight of 250.
12 g/mol and has a purity of 98% or higher.
The compound is soluble in water and other organic solvents, and it is widely used as a reagent in the synthesis of other organic compounds.
The synthesis of 3-chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride can be achieved through several different routes, each with its own advantages and disadvantages.
In this article, we will discuss some of the most commonly used synthetic routes for this compound.
Route 1: via 3-chloro-6-bromo-pyridazine
One of the most commonly used synthetic routes for 3-chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride is via 3-chloro-6-bromo-pyridazine.
To prepare 3-chloro-6-bromo-pyridazine, a reaction between pyridazine and chloroacetic acid is carried out.
The reaction is as follows:
C5H5N3 + CO2H → C5H5N3CO2H
After the completion of this reaction, the product is recrystallized to remove any impurities.
The resulting 3-chloro-6-bromo-pyridazine is then treated with piperidine to obtain 3-chloro-6-(piperidin-3-yloxy)-pyridazine.
The product is then treated with hydrogen chloride to obtain the hydrochloride salt.
Route 2: via 3-chloro-6-[2-(piperidin-1-yl)ethoxy]-pyridazine
Another synthetic route for 3-chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride is via 3-chloro-6-[2-(piperidin-1-yl)ethoxy]-pyridazine.
To prepare 3-chloro-6-[2-(piperidin-1-yl)ethoxy]-pyridazine, a reaction between 2-chloro-6-[2-(piperidin-1-yl)ethoxy]-pyridazine and potassium hydroxide is carried out.
The reaction is as follows:
C8H11Cl2N3O + KOH → C8H11Cl2N3OK
After the completion of this reaction, the product is treated with hydrochloric acid to obtain 3-chloro-6-[2-(piperidin-1-yl)ethoxy]-pyridazine hydrochloride.
Route 3: via 3-chloro-6-[[2-[(4-chlorophenyl)methyl]-2H-pyrazol-3-yl]oxy]-pyridazine
Another synthetic route for 3-chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride is via 3-chloro-6-[[2-[(4-chlorophenyl)methyl]-2H-pyrazol-3-yl]oxy]-pyridazine.
To prepare 3-chloro-6-[[2-[(4-chlorophenyl)methyl]-2H-pyrazol-3-yl]oxy]-pyridazine, a reaction between 2-bromo-6-
