The Synthetic Routes of 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)

In the chemical industry, the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI) is an important process that is widely used in the production of various chemicals, pharmaceuticals, and other products.
There are several synthetic routes that can be used to produce this compound, each with its own advantages and disadvantages.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI) in the chemical industry.

1. The Ashwell-Henderson method
   The Ashwell-Henderson method is one of the most commonly used synthetic routes for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI).
   This method involves the reaction of 2,4-dinitrophenylhydrazine with Acetic anhydride in the presence of an alcohol solvent.
   The reaction is carried out in several steps, with the intermediate products being isolated and purified at each stage.
   The final product is then obtained by reacting the purified intermediate products with a methylester.
   
2. The Reinecke-Albers method
   The Reinecke-Albers method is another commonly used synthetic route for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI).
   This method involves the reaction of o-toluidine with methyl iodide in the presence of an acid catalyst, such as sulfuric acid or hydrochloric acid.
   The reaction produces the desired product, which can then be purified and used as needed.
   
3. The Amos method
   The Amos method is a synthetic route that involves the reaction of chloroform with 6-methylpyridazine-3-carboxaldehyde in the presence of an acid catalyst, such as sulfuric acid or phosphoric acid.
   The reaction produces the desired product, which can then be purified and used as needed.
   
4. The Knorr-Voigt method
   The Knorr-Voigt method is a synthetic route that involves the reaction of 2-nitro-4,6-dimethylpyrimidine with methyl iodide in the presence of an acid catalyst, such as sulfuric acid or hydrochloric acid.
   The reaction produces the desired product, which can then be purified and used as needed.
   

In conclusion, there are several synthetic routes that can be used for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI) in the chemical industry.
Each of these routes has its own advantages and disadvantages, and the choice of route will depend on various factors, such as the availability of raw materials, the desired yield, and the purity of the final product.
Chemical companies must carefully evaluate these factors when deciding which synthetic route to use for the production of this compound.