Home > Medical News > Medical World News > The Synthetic Routes of 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)

The Synthetic Routes of 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)

  • Last Update: 2023-05-18
  • Source: Internet
  • Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

In the chemical industry, the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI) is an important process that is widely used in the production of various chemicals, pharmaceuticals, and other products.
There are several synthetic routes that can be used to produce this compound, each with its own advantages and disadvantages.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI) in the chemical industry.


  1. The Ashwell-Henderson method
    The Ashwell-Henderson method is one of the most commonly used synthetic routes for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI).
    This method involves the reaction of 2,4-dinitrophenylhydrazine with Acetic anhydride in the presence of an alcohol solvent.
    The reaction is carried out in several steps, with the intermediate products being isolated and purified at each stage.
    The final product is then obtained by reacting the purified intermediate products with a methylester.
  2. The Reinecke-Albers method
    The Reinecke-Albers method is another commonly used synthetic route for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI).
    This method involves the reaction of o-toluidine with methyl iodide in the presence of an acid catalyst, such as sulfuric acid or hydrochloric acid.
    The reaction produces the desired product, which can then be purified and used as needed.
  3. The Amos method
    The Amos method is a synthetic route that involves the reaction of chloroform with 6-methylpyridazine-3-carboxaldehyde in the presence of an acid catalyst, such as sulfuric acid or phosphoric acid.
    The reaction produces the desired product, which can then be purified and used as needed.
  4. The Knorr-Voigt method
    The Knorr-Voigt method is a synthetic route that involves the reaction of 2-nitro-4,6-dimethylpyrimidine with methyl iodide in the presence of an acid catalyst, such as sulfuric acid or hydrochloric acid.
    The reaction produces the desired product, which can then be purified and used as needed.

In conclusion, there are several synthetic routes that can be used for the synthesis of 3-pyridazinecarboxylic acid, 6-methyl-, methylester (9CI) in the chemical industry.
Each of these routes has its own advantages and disadvantages, and the choice of route will depend on various factors, such as the availability of raw materials, the desired yield, and the purity of the final product.
Chemical companies must carefully evaluate these factors when deciding which synthetic route to use for the production of this compound.


This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Contact Us

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.