The Synthetic Routes of 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE

4-Chloro-2-(trifluoromethyl)quinoline is an important synthetic intermediate in the chemical industry, with a wide range of applications in the pharmaceutical, agrochemical, and chemical industries.
The synthetic routes of 4-chloro-2-(trifluoromethyl)quinoline can be broadly classified into two categories: direct synthesis and indirect synthesis.

Direct Synthesis
The direct synthesis of 4-chloro-2-(trifluoromethyl)quinoline involves the reaction of 2-chloro-1,3-oxazole with trifluoroacetic acid in the presence of a Lewis acid catalyst, such as AlCl3.
The reaction results in the formation of 2-(trifluoromethyl)quinoxaline, which can then be converted to 4-chloro-2-(trifluoromethyl)quinoline by treating it with chloroform and HCl.

Indirect Synthesis
The indirect synthesis of 4-chloro-2-(trifluoromethyl)quinoline involves the synthesis of 2-chloro-1,3-oxazole, which is then converted to 2-(trifluoromethyl)quinoxaline, and finally to 4-chloro-2-(trifluoromethyl)quinoline.
The indirect synthesis of 4-chloro-2-(trifluoromethyl)quinoline can be achieved by several different routes, including the Grignard reaction, the Wolff-Kishner reduction, and the reduction of the corresponding nitrile.

Grignard Synthesis
One of the most common methods for the synthesis of 2-chloro-1,3-oxazole is the Grignard reaction, which involves the reaction of 1,3-oxazolidine with magnesium metal in the presence of an organic solvent.
The resulting Grignard reagent can then be treated with a variety of reagents, such as trifluoroacetic acid, to produce 2-(trifluoromethyl)quinoxaline.
The conversion of 2-(trifluoromethyl)quinoxaline to 4-chloro-2-(trifluoromethyl)quinoline can be achieved by treating it with chloroform and HCl.

Wolff-Kishner Reduction
The Wolff-Kishner reduction is another common method for the synthesis of 2-chloro-1,3-oxazole, which involves the reaction of 1,3-oxazolidine with silver metal in the presence of an organic solvent.
The resulting silver complex can then be treated with a variety of reagents, such as chloroform and HCl, to produce 2-(trifluoromethyl)quinoxaline.
The conversion of 2-(trifluoromethyl)quinoxaline to 4-chloro-2-(trifluoromethyl)quinoline can be achieved by treating it with chloroform and HCl.

Reductive Nitration
The reduction of the corresponding nitrile is another method for the synthesis of 2-chloro-1,3-oxazole, which can be achieved by treating the nitrile with lithium aluminum hydride (LiAlH4) in the presence of an organic solvent.
The resulting 2-chloro-1,3-oxazole can then be converted to 2-(trifluoromethyl)quinoxaline and finally to 4-chloro-2-(trifluoromethyl)quinoline by treating it with chloroform and HCl.

Overview
The synthesis of 4-chloro-2-(trifluorom