The Synthetic Routes of 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-Amino-3,4-dihydro-2H-isoquinolin-1-one, also known as tryptamine, is a naturally occurring compound that has been studied extensively in the field of medicinal chemistry.
It has been found to have a wide range of biological activities, including anti-inflammatory, analgesic, and anti-tumor properties.
As a result, tryptamine has been the subject of much research and has been synthesized using a variety of methods.

One of the earliest methods used for the synthesis of tryptamine involved the reduction of indole-3-acetaldehyde using sodium borohydride.
This reaction involved the reduction of the aldehyde group of the indole-3-acetaldehyde to form the corresponding alcohol, which was then reduced further to form tryptamine.

Another early method for the synthesis of tryptamine involved the reduction of indole-3-acetic acid using lithium aluminum hydride (LiAlH4).
This involved the reduction of the carboxyl group of the acid to form the corresponding alcohol, which was then reduced further to form tryptamine.

In more recent years, a number of synthetic routes for tryptamine have been developed that take advantage of advances in organic chemistry.
One such route involves the use of a reagent called CAN, which is a dehydrating agent that has been used to form carbon-carbon bonds in organic molecules.

The synthesis of tryptamine using CAN involves the preparation of a derivative of tryptamine called N-Boc-tryptamine.
This derivative is then treated with CAN in the presence of a base such as sodium hydroxide.
The CAN reagent dehydrates the intermediate formed in the reaction, forming a double bond between the carbon atoms.
The double bond is then reduced using a reducing agent such as lithium alanine to form the final product, tryptamine.

Another recent synthetic route for tryptamine involves the use of a reagent called oxalyl chloride.
This reagent is a strong acid that has been used to form carbon-carbon bonds in organic molecules.

The synthesis of tryptamine using oxalyl chloride involves the preparation of a derivative of tryptamine called N-Boc-tryptamine.
This derivative is then treated with oxalyl chloride in the presence of a solvent such as dichloromethane.
The oxalyl chloride reagent reacts with the carboxyl group of the derivative to form a new carbon-carbon bond.
The resulting compound is then treated with a reducing agent such as lithium alanine to form the final product, tryptamine.

In conclusion, there are a variety of synthetic routes for the synthesis of tryptamine, each with its own advantages and disadvantages.
These routes range from traditional methods that have been used for many years to more recent methods that take advantage of advances in organic chemistry.
Regardless of the method used, the synthesis of tryptamine remains an important and active area of research in the field of medicinal chemistry.