The Synthetic Routes of 6-aMino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyriMidine-2,4(1H,3H)-dione

6-Amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyriMidine-2,4(1H,3H)-dione is a heterocyclic compound that has been found to possess certain pharmacological activities such as anti-inflammatory, antinociceptive, and antiplatelet effects.
Therefore, it is of great interest to the pharmaceutical industry for the development of new drugs.
The synthesis of this compound involves several steps, which can be achieved through various synthetic methods.
In this article, we will discuss the synthetic routes of 6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyriMidine-2,4(1H,3H)-dione.

Synthetic Route 1: via isonicotinic acid hydrazide

The first synthetic route for the preparation of 6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyriMidine-2,4(1H,3H)-dione involves the synthesis of isonicotinic acid hydrazide, which is then converted to the desired compound.

Step 1: Synthesis of isonicotinic acid hydrazide

Isonicotinic acid hydrazide is synthesized by reacting isonicotinic acid with hydrazine.
The reaction is carried out in the presence of a solvent such as acetonitrile or DCM.
The reaction is exothermic, and the temperature is maintained using a water bath or an ice bath.

Step 2: Synthesis of 6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyriMidine-2,4(1H,3H)-dione

Isonicotinic acid hydrazide is then treated with 2-fluoro-4-iodophenylamine and triethylamine in the presence of a solvent such as DMF or DMSO.
The reaction is allowed to proceed at room temperature for several hours.
The product is then isolated by precipitation with ethyl acetate and purified by column chromatography using a solvent such as silica gel or alumina.

Synthetic Route 2: via 6-amino-3-cy