The Synthetic Routes of 6-AMINOQUINOLINE HYDROCHLORIDE

6-Aminoquinoline hydrochloride is a compound that is widely used in the chemical industry for various purposes.
Its synthetic routes are diverse and depend on the specific needs of the application.
In this article, we will discuss some of the common synthetic routes of 6-aminoquinoline hydrochloride.

1. The Purine-Synthon Method
   One of the most commonly used methods for synthesizing 6-aminoquinoline hydrochloride is the Purine-Synthon method.
   This method involves the condensation of N-methyl-6-amino-quinazoline-2-carboxylic acid with cyanogen bromide to form N-methyl-6-amino-quinazoline-2-cyanide.
   The compound is then treated with hydrochloric acid to form 6-aminoquinoline hydrochloride.
   
2. The Mannich Reaction
   The Mannich reaction is another popular method for synthesizing 6-aminoquinoline hydrochloride.
   In this method, 2-chloro-1,3-oxazolidine is treated with formaldehyde and then condensed with an aromatic aldehyde in the presence of sodium hydroxide.
   The resulting compound is then treated with N-methyl-6-amino-quinazoline-2-carboxylic acid to form 6-aminoquinoline hydrochloride.
   
3. The Hydrolysis of N-(4-Chloro-2-methyl-6-nitrophenyl) 6-Aminoquinoline-2-Carboxamide
   N-(4-Chloro-2-methyl-6-nitrophenyl) 6-aminoquinoline-2-carboxamide can be synthesized from N-methyl-6-amino-quinazoline-2-carboxylic acid and chloroform.
   The resulting compound is then treated with sodium hydroxide to form 6-aminoquinoline hydrochloride.
   
4. The Reduction of N-(4-Chloro-2-methyl-6-nitrophenyl) 6-Aminoquinoline-2-Carboxamide
   N-(4-Chloro-2-methyl-6-nitrophenyl) 6-aminoquinoline-2-carboxamide can also be synthesized from N-methyl-6-amino-quinazoline-2-carboxylic acid and chloroform, and then treated with lithium aluminum hydride to form 6-aminoquinoline hydrochloride.
   

In conclusion, synthesizing 6-aminoquinoline hydrochloride requires the use of different methods, depending on the specific requirements of the application.
The methods discussed above are some of the most commonly used in the chemical industry, and they offer a range of options for those looking to synthesize this compound.
With the right synthetic route, it is possible to produce 6-aminoquinoline hydrochloride in high yields and with high purity, making it an essential compound for various industrial applications.