The Synthetic Routes of 6-cyclopropylpyridazin-3-amine

6-cyclopropylpyridazin-3-amine is a synthetic compound that is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs.
The synthesis of this compound involves several steps and can be accomplished through different routes.
In this article, we will discuss the synthetic routes of 6-cyclopropylpyridazin-3-amine and their significance in the chemical industry.

1. Synthetic Route 1: Via N-methyl pyrrole and N-methyl acetamide

This route involves the synthesis of N-methyl pyrrole followed by its condensation with N-methyl acetamide.
The product is then hydrolyzed to obtain 6-cyclopropylpyridazin-3-amine.
This route is known for its simplicity and ease of operation, and is often used as an introduction to the synthesis of more complex compounds.

2. Synthetic Route 2: Via 2,4-diamino-6-chloropyrimidine and 2-cyanopyrrole

This route involves the synthesis of 2,4-diamino-6-chloropyrimidine followed by its condensation with 2-cyanopyrrole.
The product is then hydrolyzed to obtain 6-cyclopropylpyridazin-3-amine.
This route is known for its high yield and is often used in industrial-scale production.

3. Synthetic Route 3: Via hydraZone and oxalic acid

This route involves the synthesis of hydrazone followed by its hydrolysis using oxalic acid to obtain 6-cyclopropylpyridazin-3-amine.
This route is known for its ease of operation and is often used in the synthesis of other compounds.

4. Synthetic Route 4: Via Suzuki reaction and hydrolysis

This route involves the synthesis of 6-bromopyridazine-3-carboxylic acid followed by its treatment with sodium hydroxide to obtain 6-cyclopropylpyridazin-3-amine.
This route is known for its high yield and is often used in industrial-scale production.

In conclusion, the synthetic routes of 6-cyclopropylpyridazin-3-amine are numerous and vary in their complexity and yield.
These routes are widely used in the pharmaceutical industry and are essential for the synthesis of various drugs.
The choice of route depends on several factors, including the desired yield, the availability of reagents, and the scale of production.
The development of new routes and the optimization of existing ones are ongoing processes in the chemical industry and are essential for the continued progress and growth of this field.