The Synthetic Routes of Atomoxetine Related Compound C (10 mg) (N-methyl-3-phenyl-3-(p-tolyloxy)propan-1-amine hydrochloride)

Atomoxetine is a medication used to treat attention-deficit/hyperactivity disorder (ADHD) in adults and children.
It works by increasing the levels of certain chemicals in the brain, such as dopamine and norepinephrine, which play a role in attention and impulse control.
Synthetic routes of Atomoxetine related compound C (10 mg) (N-methyl-3-phenyl-3-(p-tolyloxy)propan-1-amine hydrochloride) have been widely studied and developed in the chemical industry.

One of the most common synthetic routes for Atomoxetine related compound C involves starting with a reaction between p-tolyl isocyanate and N-methyl-3-phenylpropanamine in the presence of a solvent like DMF.
The resulting product is then treated with hydrochloric acid to generate the hydrochloride salt.
This route requires the use of hazardous reagents such as isocyanates and aromatic amines, and it produces a compound that is sensitive to moisture and air.

Another synthetic route for Atomoxetine related compound C involves starting with N-methyl-3-phenyl-3-(p-tolylsulphonyl)propanamine, which is synthesized by reacting N-methyl-3-phenylpropanamine with p-tolylsulphonyl chloride in the presence of a solvent like DMF.
The resulting product is then treated with hydrochloric acid to generate the hydrochloride salt.
This route also requires the use of hazardous reagents, and it produces a compound that is sensitive to moisture and air.

A less hazardous synthetic route for Atomoxetine related compound C involves starting with N-methyl-3-phenyl-2-(p-tolyl-sulphonyl)acetamide, which is synthesized by reacting N-methyl-3-phenyl-acetamide with p-tolylsulphonyl chloride in the presence of a solvent like DMF.
The resulting product is then treated with hydrochloric acid to generate the hydrochloride salt.
This route does not require the use of hazardous reagents, and it produces a compound that is less sensitive to moisture and air.

In recent years, researchers have developed more efficient and less hazardous synthetic routes for Atomoxetine related compound C.
One such route involves starting with N-methyl-3-phenyl-1,2,3,4-tetrahydroquinoxaline-2,4-diamine, which is synthesized by reacting N-methyl-3-phenyl-1,2,3,4-tetrahydroquinoxaline-2,4-diamine with a compound like diisopropyl azodicarboxylate in the presence of a solvent like DMF.
The resulting product is then treated with hydrochloric acid to generate the hydrochloride salt.
This route does not require the use of hazardous reagents, and it produces a compound that is less sensitive to moisture and air.

In conclusion, there are several synthetic routes for Atomoxetine related compound C that have been developed in the chemical industry.
While some of these routes involve the use of hazardous reagents and produce compounds that are sensitive to moisture and air, others are less hazardous and produce compounds that are less sensitive to these factors.
As research continues, it is likely that more efficient and less hazardous synthetic routes for Atomoxetine related compounds will be developed.