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Imatinib mesylate, also known as Glivec, is a medication used to treat various types of cancer, including chronic myeloid leukemia, gastrointestinal stromal tumors, and dermatofibrosarcoma protuberans.
It is an important drug in the treatment of these diseases, and has been credited with improving the survival rates of patients with these conditions.
One of the key advantages of imatinib mesylate is its ability to target specific cancer-causing cells and proteins, without harming healthy cells.
This is due to its selective tyrosine kinase inhibition property, which prevents the growth and spread of cancer cells.
The synthetic route for imatinib mesylate involves several steps, including the synthesis of the precursor compound, 2-[4-(3-chloro-4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenoxy)benzyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine.
This compound is then converted into the final product, imatinib mesylate, through the use of various chemical reactions and purification techniques.
The synthesis of 2-[4-(3-chloro-4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenoxy)benzyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine involves several steps, including the synthesis of the starting materials, the condensation reactions, and the final deprotection steps.
The synthesis of imatinib mesylate involves the use of several chemical reactions, including hydrogenation, halogenation, sulfonation, and aromatization.
These reactions are carried out in a series of steps, each of which is designed to yield the desired intermediate product.
In conclusion, the synthetic routes of imatinib mesylate are complex and involve several steps, each of which is carefully designed to yield the final product.
The drug is an important treatment for various types of cancer, and its ability to target specific cancer-causing cells and proteins without harming healthy cells makes it a valuable tool in the fight against these diseases.