The Synthetic Routes of iMatinib related substance C

Introduction:

Matrine is a natural product derived from the bark of the Sanguinaria canadensis tree and has been used in traditional medicine for centuries.
It has been found to have anti-inflammatory, analgesic, and anticancer properties, making it a promising compound for the development of new cancer treatments.
However, the supply of natural matrine is limited, making it difficult to scale up production for clinical use.
This has led to the development of synthetic routes to matrine and its analogs in the chemical industry.
In this article, we will focus on the synthetic routes of iMatinib, a synthetic analog of matrine, specifically C.

Background:

Matrine is a benzophenoxazine alkaloid that is extracted from the bark of the Sanguinaria canadensis tree.
It has been found to have a wide range of biological activities, including anti-inflammatory, antiviral, and anticancer properties.
Its anticancer properties have been attributed to its ability to inhibit proliferation and induce apoptosis in cancer cells.

The natural supply of matrine is limited, and efforts have been made to develop synthetic routes to this compound.
One of the synthetic routes to matrine is through the use of hydrazone derivatives as intermediate.
This method involves the formation of a hydrazone intermediate, which is then reduced to form matrine.

Synthetic routes to iMatinib:

There are several synthetic routes to iMatinib, each with its own advantages and disadvantages.
In this section, we will discuss some of the most commonly used synthetic routes to iMatinib.

1. Synthetic route using hydrazone derivatives

This route involves the formation of a hydrazone intermediate, which is then reduced to form iMatinib.
The starting material for this route is typically a nitro or nitroso compound, which is converted into a hydrazone derivative through a series of steps.
The hydrazone derivative is then reduced to form iMatinib.

Advantages:

• This route is relatively straightforward and can be performed in a single step.
  
• It uses readily available starting materials.
  

Disadvantages:

• The yield of iMatinib can be low.
  
• The method is sensitive to air and moisture.
  

1. Synthetic route using a Suzuki-Miyaura reaction

This route involves the use of a Suzuki-Miyaura reaction to synthesize iMatinib.
The starting material for this route is typically a boronic acid derivative, which is reacted with a phenylboronic acid derivative in the presence of a palladium catalyst to form iMatinib.

Advantages:

• This route can be performed in a one-pot reaction, making it convenient and efficient.
  
• The yield of iMatinib is typically high.
  

Disadvantages:

• The method requires the use of a metal catalyst and can be expensive.
  
• The starting material can be expensive and difficult to obtain.
  

1. Synthetic route using a Williamson ether synthesis

This route involves the use of a Williamson ether synthesis to synthesize iMatinib.
The starting material for this route is typically an aldehyde or ketone, which is treated with a Grignard reagent and an aqueous sulfuric acid solution to form an ether intermediate.
The ether intermediate is then reduced to form iMatinib.

Advantages:

• This route can be performed in a single step.
  
• It uses easily available starting materials.
  

Disadvantages:

• The yield of iMatinib can be low.
  
• The method requires the use of strong acid and can be hazardous.
  

Conclusion:

iMatinib is a synthetic analog of matrine with promising anticancer properties.
There are several synthetic routes to iMatinib, each with its own advantages and disadvantages.
The most commonly used routes include the use of hydrazone derivatives, a Suzuki-Miyaura reaction, and a Williamson ether synthesis.
As the demand for iMatinib and its analogs continues to grow,