The Synthetic Routes of Isopropyl 3-pyridazinone-6-carboxylate

The Synthetic Routes of Isopropyl 3-pyridazinone-6-carboxylate: A Comprehensive Review in the Chemical Industry

Abstract:
Isopropyl 3-pyridazinone-6-carboxylate is an important organic compound with diverse industrial applications.
The synthesis of this compound involves several steps, and the choice of the synthetic route depends on various factors, such as the cost, availability of reagents, and the desired yield.
This article provides a comprehensive review of the different synthetic routes of isopropyl 3-pyridazinone-6-carboxylate, including the classical methods as well as the latest developments in the field.

Keywords: isopropyl 3-pyridazinone-6-carboxylate, synthesis, organic compound, chemical industry, synthetic routes, synthetic methods.

Introduction:
Isopropyl 3-pyridazinone-6-carboxylate is an important organic compound that finds application in various industries, including pharmaceuticals, agrochemicals, and dyes.
Its versatile nature and wide range of applications make it an important compound for researchers and industrialists alike.
The synthesis of isopropyl 3-pyridazinone-6-carboxylate involves several steps, and the choice of the synthetic route depends on various factors, such as the cost, availability of reagents, and the desired yield.

Classical Synthetic Routes:
The classical synthetic routes of isopropyl 3-pyridazinone-6-carboxylate include the Lossen rearrangement, the Peterson olefination, and the Pauson-Khand reaction.
The Lossen rearrangement involves the conversion of a substituted benzaldehyde into a substituted salicylaldehyde through a rearrangement reaction.
The Peterson olefination involves the conversion of a substituted salicylaldehyde into a substituted fatty acid through a series of reaction steps.
The Pauson-Khand reaction involves the conversion of a substituted salicylaldehyde into a substituted 2,5-dihydrofuran-3-carboxylate through a series of reaction steps.

Recent Synthetic Routes:
In recent years, several newer synthetic routes for isopropyl 3-pyridazinone-6-carboxylate have been developed, which offer advantages over the classical methods.
These newer methods include the use of microwave irradiation, the Suzuki-Miyaura reaction, the Stiefel reaction, the Sonogashira coupling reaction, and the Heck reaction.
The use of microwave irradiation has been shown to greatly accelerate the reaction kinetics, thereby reducing the reaction time and the cost of the reaction.
The Suzuki-Miyaura reaction involves the coupling of a substituted boronic acid with a substituted phenylboronic acid to form a substituted coumarin, which can then be converted into isopropyl 3-pyridazinone-6-carboxylate.
The Stiefel reaction involves the conversion of a substituted salicylaldehyde into a substituted 2,5-dihydrofuran-3-carboxylate through a series of reaction steps, which can then be converted into isopropyl 3-pyridazinone-6-carboxylate.
The Sonogashira coupling reaction involves the coupling of a substituted phenylboronic acid with a substituted aryl halide to form a substituted coumarin, which can then be converted into isopropyl 3-pyridazinone-6-carboxylate.
The Heck reaction involves the coupling of a substituted aryl halide with a substit