The team of Ding Kefeng and Wang Di of Zhejiang University revealed the mechanism by which potassium ions regulate macrophage immune metabolism in the tumor microenvironment

This article is the original of translational medicine network, please indicate the source when reprinting

Author: Jevin

The tumor microenvironment (TME) is a unique niche controlled

On September 13, 2022, Professor Wang Di and Professor Ding Kefeng of Zhejiang University jointly published a research paper online in Cell Metabolism, which revealed the anti-tumor ability of high K+ inhibition of tumor-associated macrophages (TAM) in tumors

#relatedArticles

The dual function of TAM

 01 

Tumor-associated macrophages (TAMs) form dynamic and heterogeneous cell populations within and between tumors

Macrophage conditional knockout

 02

The team at Zhejiang University used a variety of mouse tumor models and human clinical tumor samples to find that high K+ in tumors showed inhibitory effect

Potential targets for TAM's anti-tumor capabilities

 03 

Further studies have shown that Kir2.

Finally, the researchers evaluated the therapeutic potential of pharmacologically targeted Kir2.

Kir2.

The results of the study showed that in the tumor microenvironment of ion disturbances, Kir2.

Resources:

#relatedArticles

Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for

Testimonials/ Live Events

September 27, 14:00-17:30 Shanghai

Innovative technology to help tumor accurate diagnosis and treatment summit forum

Scan the code to participate for free

November 03-04 09:00-17:30 Shanghai

The 3rd Yangtze River Delta In Vitro Diagnostic Industry Forum

Scan the code to participate for free

November 11-25 27:09-00:17 Shanghai

The 4th Shanghai International Conference on Cancer

Scan the code to participate