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5-Methyl-tetrahydrofolic acid disodium salt, also known as 5-MTHF, is a synthetic form of folic acid that is commonly used in the chemical industry.
It is a critical ingredient in many chemical reactions and is used to produce a wide range of products, including pharmaceuticals, cosmetics, and agricultural chemicals.
Upstream Products
The production of 5-MTHF is a complex process that involves several steps, including the synthesis of 5-methyl-tetrahydrofolic acid and its conversion into the disodium salt.
The raw materials required for the production of 5-MTHF include precursors such as 5,6,7,8-tetrahydrofolic acid, glycine, and para-aminobenzoic acid.
These raw materials are then transformed into 5-methyl-tetrahydrofolic acid through a series of chemical reactions that involve the use of reagents such as hydrochloric acid, sodium hydroxide, and hydrogen peroxide.
Once 5-methyl-tetrahydrofolic acid is synthesized, it is converted into the disodium salt through a process known as salt formation.
This involves the reaction of 5-methyl-tetrahydrofolic acid with sodium hydroxide to form the dihydrochloride salt, which is then hydrolyzed to produce the disodium salt.
The disodium salt of 5-MTHF is a white, crystalline solid that is highly soluble in water and has a strong, unpleasant odor.
Downstream Products
5-MTHF is used in a wide range of downstream products in the chemical industry.
It is a key intermediate in the production of many pharmaceuticals, including anti-convulsants, anti-folates, and anti-cancer drugs.
It is also used in the production of cosmetics, such as hair dyes and skin care products, and agricultural chemicals, such as herbicides and insecticides.
One of the most common downstream products of 5-MTHF is the antiepileptic drug levetiracetam.
This drug is used to treat epileptic seizures and is synthesized through a series of chemical reactions that involve the use of 5-MTHF as a key intermediate.
Other pharmaceuticals that use 5-MTHF as an intermediate include pemetrexed, which is used to treat cancer, and folic acid itself, which is used to prevent neural tube defects in pregnant women.
In addition to its use in pharmaceuticals, 5-MTHF is also used in the production of a range of cosmetics and personal care products.
For example, it is used as a precursor in the synthesis of hair dyes and is also used in the production of skin care products, such as anti-aging creams and moisturizers.
5-MTHF is also used in the production of agricultural chemicals, such as herbicides and insecticides.
It is used as a precursor in the synthesis of ethephon, a plant growth regulator that is used to promote fruit set in crops such as grapes, peaches, and cherries.
It is also used in the production of the insecticide diflubenzuron, which is used to control pests such as aphids, thrips, and whiteflies.
Production and Supply Chain
The production of 5-MTHF involves several steps, as outlined above, and requires the use of a range of raw materials and reagents.
The production process is generally carried out in specialized chemical plants that are equipped with the necessary equipment and infrastructure to handle hazardous chemicals and to ensure the safety of workers and the environment.
The supply
