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| The U. The National Institutes of Health (NIH) has previously allocated approximately US$190 million to support the research of the Somatic Cell Genome Editing (SCGE) Consortium. Genetic factors are the "culprits" that cause most human diseases, including genetic diseases, infectious diseases and many malignant diseases. At present, gene therapy is achieving greater and greater success, but scientists believe that the field of somatic gene editing requires new editing, delivery and biological systems to better measure the safety and effectiveness of various strategies. This time, a joint research team including the University of Wisconsin and the University of Massachusetts published opinions and introduced and discussed related plans, including: developing new technologies to induce and evaluate genome editing, and determine the downstream functional consequences of genome editing in human cells; At the same time, it adheres to a rigorous and innovative method to verify through third-party testing of small and large animals; and then visualize the "assembled" SCGE "toolkit" and the knowledge generated by the application to accelerate researchers' understanding of various diseases Clinical development of new therapies. The article stated that this project will strictly focus on somatic cell editing, focusing on two aspects: one is from the DNA in the nucleus to the nucleic acid elsewhere in the cell; the other is not changing the DNA or RNA sequence to produce chromatin structure The targeted change is the targeted epigenome editing. The plan will also establish a common indicator or standard, and then compare multiple technologies.
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