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The Zheng Junke research group of the School of Basic Medical Sciences published in Blood the new bone marrow microenvironment component to maintain the stemness of hematopoietic stem cells...

 Last Update: 2022-01-10
 Source: Internet
 Author: User

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Recently, the research group of researcher Zheng Junke from the School of Basic Medicine published a research paper entitled "Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches" online in Blood, an internationally renowned journal in the field of blood
.

Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate into all hematopoietic cells, and are one of the important adult stem cells that maintain the normal life functions of humans
.

With the development of bone marrow transplantation technology, HSCs have been widely used in clinical treatment of various blood system diseases, such as leukemia, lymphoma, anemia, and immune diseases

This study specifically knocked out the expression of angiopoietin-like protein 2 (Angptl2) in mouse Niche endothelial cells, mesenchymal stem cells, and megakaryocytes, confirming that only ANGPTL2 derived from vascular endothelial cells can maintain HSCs Self-renewal ability
.

Knockout of Angptl2, which is the source of endothelial cells, can lead to the decline of HSCs' ability to locate in the perivascular microenvironment and the loss of resting state

Diagram of the working mode of ANGPTL2 derived from endothelial cells in bone marrow microenvironment regulating the stemness of HSCs

Researcher Yu Zhuo from the Department of Pathophysiology of School of Basic Medical Sciences and PhD student Yang Wenqian are the co-corresponding authors of this paper
.

Researcher Zheng Junke, Researcher Yu Zhuo, Assistant Researcher Zhang Yaping and Xie Li experimentalist are the co-corresponding authors of the paper .

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