There are three basic principles for validating brain nerve cell regeneration therapy

Science and Technology Daily (Fu Xuan reporter Wang Chun) Recently, Peng Bo's research group of the Institute of Brain Science Translation of Fudan University, Mao Ying's research group of Huashan Hospital Affiliated to Fudan University, and Yuan Tifei's research group of Shanghai Mental Health Center used live cell imaging, rigorous NeuroD1-mediated microglia-neuron reprogramming has been systematically explored by lineage tracing and pharmacology

The brain is mainly composed of neurons and glial cells, and the number of the two is about 1:1

Microglia are the most regenerative glial cells in the brain

The joint research group proposed three basic principles for the rigorous validation of endogenous nerve regeneration therapy: rigorous lineage tracing to prove its origin; clear in vivo/live cell imaging to observe the transition process of glial cells to neurons; clearance of this type of glial Plasma cells were negatively verified

In addition, Peng Bo's research group from Fudan University developed three schemes using the regenerative ability of microglia in the early stage, realizing the high-efficiency exogenous transplantation/replacement of microglia at the whole brain scale for the first time