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    Home > Active Ingredient News > Drugs Articles > There are three types of fluidized bed spray methods for FLP multi-function granulation coating machine

    There are three types of fluidized bed spray methods for FLP multi-function granulation coating machine

    • Last Update: 2022-10-03
    • Source: Internet
    • Author: User
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    FLP multi-function granulation coating machine is a new type of equipment that integrates strong electricity, weak electricity, hydraulic and pneumatic power for the transformation of the original ordinary sugar coating machine
    .

    It is mainly composed
    of the main engine (original sugar coating machine), controllable room temperature hot air system, automatic liquid supply and gas spray system, etc.

    During fluidized bed granulation or granular coating, the spraying method
    should be selected according to the material performance and the planned product quality.

    At present, there are three
    kinds of fluidized bed spray methods: top spray, tangential spray, and bottom spray.

    1.
    Top spray is suitable for most products
    of top jet fluidized agglomeration.

    The resulting particles are characterized by porous surfaces and gap cavities and have a small
    bulk density.

    Because granules or pellets are easy to disintegrate, such as the drying granules of traditional Chinese medicine extracts, it is an effective way
    to increase the dissolution of insoluble drugs.

    2.
    FLP multi-function granulation coating machine tangential spray uses the centrifugal force generated by the rotation of the turntable to obtain a high-intensity mixing effect, combined with the drying efficiency of the fluidized bed, to produce products with high bulk density but still a small amount of gap and tooth
    decay.

    The particles are hard, not easily broken, and close to spherical
    .

    This is a common method
    for preparing granules.

    3.
    The bottom end spray is to place the nozzle in the guide tube in the center of the airflow distribution plate, and the fluidized particles, pills or tablets receive the adhesive or coating solution in the guide tube
    .

    It is a commonly used pellet coating method, which has the advantages
    of high coating efficiency and difficult adhesion of pellets.

    The above three spray methods of the FRP multi-function granulation coating machine can be used for the preparation and coating of particles and pellets in fluidized beds, but tablet coating is limited to the bottom spray type
    .

    At the heart of the fluidized bed granulation and coating process is the liquid spray system
    .

    In almost all fluidized bed equipment, the role of the nozzle is twofold, namely granulation and coating
    .

    The liquid is ejected through the orifice at low pressure and atomized
    by the air flow.

    This nozzle can produce small droplets, which is an advantage for the coating of particles or particles, but as the evaporation surface increases, the small droplets quickly transform into solid concentrates as they move forward, and their viscosity also increases
    .

    If the spray speed, solution concentration and fluidization temperature are not properly matched, when some small droplets contact the particles or particle surfaces, they cannot spread evenly, forming incomplete films or particles or particles forming unevenly, and even forming adhesives or coating materials to dry into particles or particles, resulting in unstable or unqualified
    product quality.

    If the solvent evaporation heat of the atomization solution is low, the problem will be more serious
    .

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