There is a new method for the rapid synthesis of large ring biome molecules.

Jeffrey Johnston, a professor in the Department of Chemistry at Vanderburg University in the United States, and his students have developed a new synthesis technique that can reduce the synthesis of cyclopeptides, an important ring molecule in organisms, from the previous 14 steps to six steps, with higher yields and larger ring molecule sizes.
process will open up new chemical applications, with larger ring peptides having unique biological properties that can be used to develop more efficient antibiotics, antiretroviral drugs, and pesticides.
peptide plays an important role in organic life, is used by many microorganisms to attack the opponent's chemical weapons, and has the ability to resist the virus.
for a long time, it has been difficult for such molecules, especially large ring molecules, to be synthesized by chemical methods, and the existing methods require many intermediate steps, which are not only time-consuming, but also greatly reduce yields.
The study, published online in the Proceedings of the National Academy of Sciences, says the new approach eliminates the need for these "red tape" intermediate steps, with many ring peptides available in just one step and the number of atoms in the ring much higher than natural cyclotides.
they used a commonly used reaction of organic synthesis, the photolytic reaction, which synthesizes chemical bonds such as carbon-oxygen at once.
different chemical modification units into the pre-synthetic polymer monomer, they synthesize different bioactive molecules.
Johnston also found that by adding different salts, they were able to control the ring size of the same monolithic synthetic product, the number of atoms in the ring.
they used the same monotone to introduce sodium fluoroborate and synthesize the pesticide's basic structural unit, the cyclo-shrink peptide, which contains 24 atoms in the ring, and the chemical process, which previously required 14 steps to eventually synthesize, has now been reduced to six steps.
the researchers synthesized 36 atoms of cyclopeptides after introducing potassium fluoroborate, and 60 atoms of cyclopeptides after the introduction of cesium chloride.
"these salts are like templates, and different sizes of salts can be used to synthesize ring structures of different sizes."
," Johnston said.
These cyclopeptides, which have different chemical compositions and structures, bind to specific subject proteins on the cell surface, thus "putting on a hard hat" on these subjects and, depending on the design, turning them on or off and can be used to develop antiviral drugs or pesticides.
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