Thiazolidinediones have serious side effects in the treatment of diabetes mellitus

Diabetes is a very serious disease, there are many new diagnosed cases every year, and the number of deaths caused by diabetes is increasing Type 1 diabetes mainly affects children Type 1 diabetes is common in children and adolescents The body of patients can not produce insulin Insulin is an essential hormone that transforms sugar, starch and other foods into life energy This disease accounts for about 5% of the total number of diabetic patients Insulin therapy and other treatment measures help to control the disease, prolong the life span of patients and improve the quality of life Type 2 diabetes is the most common type of diabetes In the case of many people diagnosed with the disease, many people are not aware of their own high risk The disease involves insufficient insulin secretion or cell neglect of insulin A report on fluid retention caused by thiazolidine-two * ketones for diabetes mellitus is published in a report on BioScholar website abroad It is pointed out that thiazolidine-two ketones (TZDs) frequently used in the treatment of diabetes have serious side effects * it affects the kidneys and can cause fluid retention George Seki, a professor at Tokyo University in Japan, said thiazolidinediones can cause weight gain of several kilograms and sometimes lead to heart failure Seki and colleagues report that TZDs act on hormone receptors called peroxisome proliferator activated receptors (PPARs) Seki explained that PPAR is the main gene of adipocyte biology and differentiation, so it becomes the ideal target of diabetes treatment The team also found that peroxisome proliferator activated receptors directly affect renal channels.