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    Home > Medical News > Medical Science News > This toxin is more annoying than diarrhea

    This toxin is more annoying than diarrhea

    • Last Update: 2021-01-13
    • Source: Internet
    • Author: User
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    caused by E. coli can cause bloody diarrhea and kidney damage, which is one of the most serious types of food poisoning. But researchers at the University of Connecticut's Center for Health found that these dire consequences may only be external manifestations of infection, and by studying them, they found new mechanisms for specific E. coli bacteria to invade the immune system, the key of which is the Zhiga toxin, the study was published in Science-Immunology.
    E. coli lives in the intestines of many animals, and a small number of E. coli can cause diseases under certain conditions, such as gastrointestinal infections. Some E. coli can also cause urinary tract infections and even sepsis - meaning that even if people ingest very little pathogenic bacteria, they can get very sick.
    , E. coli, which produces Chiga toxins, is highly toxic, as the infections it causes can lead to diarrhea, fever, and the death of seriously infected people. Acute poisoning can be caused by infection in young children, with about 15% of young children suffering from kidney disease, and some children suffering from long-term kidney damage.
    in E. coli, which produces Chiga toxin, there is a subtype called E. coli (EHEC). This subtype is common in the intestines of ruminants, such as cattle. EHEC in beef that is not treated with qualified hygiene is likely to cause an outbreak of infection in the population.
    In recent years, such conditions have improved by severely restricting the processing of slaughterhouses, but dangers remain, such as the possibility of EHEC when liquid containing cow droppings flows through fields near slaughterhouses and on vegetables watered with cow dung.
    , infection with EHEC is often difficult to treat, and if antibiotics are not used properly, they can cause these dying bacteria to produce more chitoxins. Early in infection with EHEC, the body's immune system reacts accordingly, but EHEC is very good at attacking these parts, inhibiting them from signaling, thus "successfully" growing uncontrolled in the human gut. The key, therefore, is how to prevent the bacteria from entering the body.
    a paper by Shivapriya Vanja, an immunologist at the University of Connecticut Health Center, and her team's postdoctoral researcher, Morena Havira, reveal the specific mechanisms by which EHEC fights the immune system.
    In the human immune system, by sensing and binding cytolipid polysaccharin (LPS), inflammatory apoptosis protease can activate the corresponding molecular function, trigger apoptosis, and damage outsiders, a process that is an important mechanism for the immune system to protect against bacterial invasion.
    but when EHEC invades, this defense mechanism is compromised. To find out how EHEC can break immune defenses, the team extracted many different types of EHEC from the bacterial library and infected them with immune cells.
    team found that during the infection of the host, the expression of zhiga toxin inhibits the activity of psoriate D, which is inhibited by a cytoprine LPS sensory mechanism mediated by the protease Caspase-11, a non-classical inflammatory small body. In addition, a variety of Chiga toxin variants inhibit cytoblast LPS perception mechanisms in mice and human cells.
    addition to the discovery of new mechanisms of effect, this is the first time that the famous Zhiga toxin has been found to destroy inflammatory small bodies. Since then, the team is conducting follow-up studies to further find out why Thertotoxin specifically inhibits and to find drugs that resist this inhibitory effect. (Source: Yuan Liu, China Science Journal)
    relevant paper information:
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