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Three recombinant variants were found in the UK, and the risk of death caused by simultaneous infection with the new crown and influenza greatly increased. New crown research progresses in one week

 Last Update: 2022-05-16
 Source: Internet
 Author: User

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The efficacy of Sinovac vaccine in preventing severe cases of new crown is similar to that of Fubitai

Source: medRxiv

On March 24th, a study published on the preprint platform medRxiv demonstrated the effectiveness of the two vaccines, Fubitai vaccine and Sinovac vaccine, on mild, moderate, severe and fatal consequences caused by the new coronavirus

In all age groups, two doses of Sinovac vaccine did not protect against mild to moderate disease, and Fabitax vaccine only provided partial protection

Four-dose Pfizer vaccine reduces elderly mortality by 78%

Source: Research Square

On March 24, a study published on the preprint platform Research Square (not peer-reviewed) showed that the fourth dose of the Pfizer-BioNTech new crown vaccine can reduce the mortality rate of elderly people over 60 by 78%

The study showed that among the subjects aged 60-69, the mortality rate of the fourth injection was 0.

New nanoparticle vaccine protects against both Covid-19 and pneumococcal infections

Source: Advanced Materials

On March 24, a study published in Advanced Materials developed a new polysaccharide-binding protein by coupling the capsular polysaccharide of Streptococcus pneumoniae type 14 (PPS14) with the recombinant RBD protein of the new coronavirus.

Compared with the RBD immunogen, the PPS14-RBD-conjugated nanoparticle vaccine SCTV01B was more immunogenic and induced stronger humoral and Th1-biased T-cell immune responses in mice

3 new coronavirus recombinant variants found in the UK

Source: UK Health Security Agency

On March 25, the British Health and Safety Agency issued a report saying that three new recombinant variants of the new coronavirus were monitored, namely XD, XE and XF

The XE strain was recombined from the BA.

Simultaneous infection of the new crown and influenza increases the risk of severe illness and death

Source: the Lancet

A study published in the Lancet on March 25 found that adults who were infected with both the new coronavirus and the flu had a significantly increased risk of severe illness and death, compared with those infected with the new coronavirus alone

The research team looked at data from more than 305,000 adults hospitalised with Covid-19 in the UK between 6 February 2020 and 8 December 2021

Vaccination booster protects mice against Omicron variant

Source: Cell

On March 27, a study published in Cell found that a booster of an mRNA vaccine developed for the variant or an existing one protected mice from Omicron infection

The study showed that antibodies induced by two doses of the mRNA-1273 vaccine were unable to effectively neutralize BA.

New progress in genetic monitoring and data sharing of new coronavirus

Source: Nature Genetics

A study published in Nature Genetics on March 28 used a set of country-specific data to conduct a global landscape analysis of SARS-CoV-2 genome surveillance and genomic data

The research team constructed a series of evaluation indicators to analyze the heterogeneity of new coronavirus genetic monitoring, the characteristics and quality of genetic sequencing data, and the degree of sharing of genetic data

An inhibitor can effectively prevent and treat the new coronavirus

Source: Nature

On March 28, a study published in "Nature" described a TMPRSS2 inhibitor (N-0385) as a prevention and treatment method for pan-new coronavirus

The researchers discovered and characterized a small-molecule compound, N-0385, that exhibited low nanomolar potency and high selectivity index in inhibiting SARS-CoV-2 infection of human lung cells and donor-derived colon cells

Stroke rates drop post-pandemic or because hospitalization is not possible

Source: Candian Medical Association Journal

A March 28 study published in the Canadian Medical Association Journal found that hospital admissions for ischemic stroke decreased during the first wave and before the start of the second wave.
The hiatus rebounded, but declined further during the third wave
.

Not only in the early Covid-19 pandemic, but in subsequent outbreaks, the incidence of ischemic stroke and the number of people receiving treatment have decreased, which may mean more delays in treatment and a higher risk of in-hospital mortality
.
The researchers encouraged patients to seek treatment in an emergency, even during an outbreak
.

Newly discovered neutralizing antibody has inhibitory potential against new coronavirus

Source: Nature Communication

On March 28, a study published in "Nature Communication" found 2 neutralizing antibodies with super inhibitory potential against the wild-type and mutant strains of the new coronavirus
.

The researchers screened two high-affinity neutralizing antibodies clone2 and clone6 from immunized mice through functional experiments, both of which have competing binding epitopes that overlap with ACE2
.
The antibody clone6 can lock the three RBDs in the "downward" closed state and bind two RBDs at the same time, while the RBDs of the antibody clone2 and the new coronavirus S protein tend to be in the "upward" open state
.
At the same time, antibody clone2 and antibody clone6 showed effective preventive and therapeutic effects in humanized ACE2 transgenic mouse model
.

The results of the world's first "new crown human trial" were officially published

Source: Nature Medicine

On March 31, a paper published in "Nature Medicine" officially announced the results of the world's first "intentional infection of humans with the new crown"
.

The research team infected 34 volunteers with a small dose of the new coronavirus (10TCID50) by nasal drops
.
Subjects were quarantined for at least 14 days after vaccination until they met virological discharge criteria and followed for 1 year to assess long-term symptoms, including olfactory and neurological impairments
.
The results showed that 53% of the volunteers were infected, and the viral load peaked 5 days after inoculation, with the nasopharynx higher than the throat
.
Antibody peaks were reached 28 days after infection
.
No serious adverse reactions occurred in this trial
.
83% of infected people developed a sense of smell
.

Circular RNA vaccines serve as platforms for immunogen production

Source: Cell

A study published in Cell on March 31 reports a circular RNA (circRNA) vaccine that elicits potent neutralizing antibodies and T cell responses
.

Compared with linear mRNAs, circRNAs are highly stable due to their covalently closed loop structure, which protects them from exonuclease-mediated degradation
.
The median half-life of circRNAs in mammalian cells is at least 2.
5-fold longer than that of their linear mRNA isoforms
.
Only a few endogenous circRNAs have been shown to serve as templates for protein translation, which can be engineered to achieve protein translation via internal ribosome entry sites or incorporating m6A modifications upstream of the open reading frame
.
Therefore, the researchers envisioned that circRNAs could be used as platforms for generating immunogens
.

Infection with Covid-19 leads to increased risk of diabetes

Source: Diabetes Care

A study published April 1 in Diabetes Care found that people with Covid-19 had a greater risk of developing diabetes a year later than people who had never had Covid-19
.

Using data from 2.
77 million veterans from the Veterans Health Administration, the researchers found that about 13 out of every 1,000 people infected with COVID-19 developed diabetes a year later, about 40 percent higher than the control group
.
Almost all detected cases were type 2 diabetes, and the risk of developing diabetes was positively correlated with the severity of COVID-19 symptoms
.
Further research is needed to elucidate long-term trends in the number of new-onset diabetes and to identify possible causes
.

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