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Guide: Prostate hyperplasia long-term trouble dyslest men, a variety of drugs reasonable choice! By middle age, the various organs of the body begin to deteriorate, and for many older men, the difficulty of urinating is a big problem.
in fact, this is mainly a problem with the prostate, and benign prostate hyperplasia (BPH) is almost every elderly male will encounter problems, not only will bring urination difficulties, but also affect the quality of life of patients.
there are research statistics: China's 60-year-old and above urology outpatients BPH accounted for 47% of the composition of medical diseases, and with the increase of age, BPH patients urinating difficulties and other symptoms will increase.
BPH treatment sydds include medication and surgical treatment.
What drugs do we need to know about when older men encounter prostate hyperplasia? Today the small editor to introduce to you: what are the main drugs to treat prostate hyperplasia? At present, there are three main types of drugs for the clinical treatment of BPH. the
are: alpha1 receptor blockers, 5 alpha-phosphase inhibitors, M receptor antagonists.
are introduced to you below.
common drugs for alpha1 receptor blockers: selective alpha1 receptor blockers (polysaccharides, tratins, aphradins) and highly selective alpha1 receptor blockers (Tansorosin, Selodosin).
mechanism: Alpha1 receptor blockers reduce symptoms by reducing the kinetic obstruction of prostate and bladder outlet by inhibiting epinephrine receptors located on the smooth muscle surface of the prostate and bladder neck.
alpha1 receptors include alpha1A, alpha1B, alpha1D three subtypes: blocking alpha1A receptors can improve urination symptoms and increase the rate of urine flow, blocking alpha 1D receptors can improve the symptoms of the urination period.
alpha1 receptor blockers do not affect the volume of the prostate and PSA levels, nor does it reduce the incidence of acute urinary retention, but the existing studies show that patients with acute urinary retention BPH have a higher chance of pulling out the catheter after receiving alpha1 receptor blocker treatment.
adverse reactions: the occurrence of adverse reactions of alpha1 receptor blockers is mainly related to alpha1B subtypes, common adverse reactions include dizziness, headache, fatigue, drowsiness, hypotension, abnormal ejaculation and so on.
leveling hypotension is more likely to occur in older patients who combine cardiovascular disease or take vascular active drugs at the same time.
Note: It should be banned for older people who have pre-existing hypostiturate and low blood pressure.
, patients who take alpha1 receptor blockers may experience iris relaxation syndrome when they receive cataract surgery, so it is recommended to discontinue the drug before surgery for patients who undergo cataract surgery.
5 alpha-reductase inhibitors commonly used drugs: finasteride (inhibition of type II 5 alpha-reductase) and datestas (inhibition of I-5 alpha-reductase and type II 5 alpha-reducase).
mechanism: 5 alpha-reductase inhibitors reduce the size of the prostate and improve patients' symptoms by inhibiting the transition from testosterone to dihydrotestosterone (DHT) in the body.
long-term use of 5-alpha-reductase inhibitors can reduce the risk of acute urinary retention and surgery required for BPH and delay the progression of the disease.
is better for patients with large prostate size and higher serum PSA levels.
but 5-alpha-reductase inhibitors have a relatively slow start-up time, and existing studies have shown maximum efficacy after 6-12 months of use.
adverse reactions: common erectile dysfunction, ejaculation abnormalities, low libido, other adverse reactions include femaleization of male breasts, breast pain and rash.
results showed that the incidence of sexual function-related adverse reactions and breast pain complications caused by tamastasamine was significantly higher than that of finasteride.
usage: finasteride 5 mg, 1 time a day;
M receptor antagonists commonly used drugs: Totrodine, oxibnon (non-selective M receptor antagonists) and Solina New (selective M3 receptor antagonists) mechanism: M receptor antagonists by selectively acting on the bladder, blocking acetylcholine and the M receptor binding of interlaced urinary muscle contraction, inhibiting the involuntary contraction of the urinary muscle, thereby improving bladder urination function.
adverse reactions: dry mouth, dizziness, constipation, heart rate acceleration, cognitive impairment, difficulty urinating and blurred vision, mostly occurred within 2 weeks of medication and 66 years of age.
Precautions: For acute urinary retention high risk patients should be careful to use M receptor antagonists, forced urinary muscle contraction when weak to disable.
urinary retention, gastric retention, narrow-angle glaucoma and allergic to M receptor antagonists are banned.
usage: Solina New 5-10mg, 1 time a day; Totrod 4mg, 1 time a day.
in addition to the above 3 types of commonly used drugs, the treatment of BPH of Chinese medicine also has a lot of, here is not one list.
treatment BPH, in addition to drugs and surgery, good living habits are also essential, can be appropriate exercise, enhance resistance, avoid eating spicy and irritating food, quit alcohol, avoid urination, develop good urination habits, avoid long-term oppression will be pussy, such as sitting, cycling and so on.
.