Today's Cell cover: What happens when cells are infected with a new coronavirus?

In their paper, scientists note that as a new class of coronavirus, the new coronavirus has a "symptom-free infection" that can be contagious before symptoms appear.
know enough about how the virus changes when it infects cells.
to this end, the large team decided to use the mass spectrometry-based quantitative phosphoproteomics method to study whether the phosphorication process in the cells of the new coronavirus would be affected after infection with the common cell line.
phosphate is the key regulatory step of intracular signaling path.
understand how proteins from hosts and viruses become phosphate after infection, hopefully allowing us to understand the pathology of the disease.
, as the researchers predicted, there was a significant increase in phosphateation of many proteins at different points in time after the virus infected cells.
this includes both proteins from the new coronavirus and some host proteins that are interoperable with the new coronavirus protein.
at different points in time after infection, the phosphate process of different proteins changes differently and is related to the cycle of viral cells (Photo Source: Reference 1) Based on the dynamics of these phosphateization points, the researchers further divided them into five different groups.
Interestingly, each group can hang hooks with the life cycle of the virus - the first group will be raised within 2 hours of infection, associated with the virus entering the cell, the second group will be related to the replication of the virus and/or go out (egress), the third group will be associated with RNA processing and will be downgraded, and the fifth group will be related to the response to infection.
to be specific, CK2 and p38 MAPK are activated after infection with the new coronavirus, and a variety of cytokines are produced, eventually shutting down kinases associated with silk division, leading to the cessation of cell cycles.
addition, CK2 promotes cells to produce filopodial protrusions with budding virus particles.
was also recorded by scientists and featured on the cover of this issue of the magazine.
to understand these phosphate changes in this study (photo source: Reference 1)? Based on changes in the activity of kinases responsible for phosphatization and known drug action, scientists have found 87 different drugs and compounds that could potentially become new coronavirus infection drugs.
10 of the 87 molecules have been approved by the FDA and 53 are already in clinical trials.
researchers tested the antiviral activity of 68 drugs and compounds and identified strong antiviral potential for CK2, p38 MAPK signaling path, PIKEYVE, and CDK inhibitors, making them potential targets for the future.
: s1. Mehdi Bouhaddou et al., (2020), The Global Phosphorylation Landscape of SARS-CoV-2 Infection, Cell, DOI: