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Research Background
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Figure 1.
Structure of IND and initial assessments
Structure of IND and initial assessments
Figure 2 Assay validation of PPi production in Mtb TrpRS reaction
Figure 3 The structures and co-crystal structures of Mtb TrpRS
Table 1 Antimycobacterial activity of IND derivatives against M.
bovis BCG and Mtb H37Rv
bovis BCG and Mtb H37Rv
Figure 4 Structure analysis of the C-4'substituted IND series compounds
Figure 5 Dose-response profile of recombinant strains against IND and Y-13 in the absence or presence of ATc
▲ Table 2 FICIs of pairwise combinations of Y-13 with TB drugs in vitro
Figure 6 Isobolograms of Y-13 in combination with IPA and streptomycin
Figure 7 In vitro kill kinetics of growth inhibitors against M.
bovis BCG
bovis BCG
Table 3 Frequency of spontaneous resistant mutants of M.
bovis BCG raised against the compound
bovis BCG raised against the compound
Table 4 Mutations in the IND resistant mutants of M.
bovis BCG, identified by whole-genome sequencing
bovis BCG, identified by whole-genome sequencing
Analysis conclusion
