Tu Pengfei/Zeng Kewu's team revealed the antitumor target of cucurbitacin B

Recently, Tu Pengfei / Zeng Kewu's team from the State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmacy, Peking University published a study entitled "Allosteric regulation of IGF2BP1 as a novel strategy for the activation of tumor immune microenvironment" in the international academic journal ACS Central Science In this paper, the molecular target and mechanism of action of cucurbitacin B, the active ingredient of guar thorn in traditional Chinese medicine, have been elucidated in dept.

Active components of traditional Chinese medicine have diverse structures and complex functions, which are an important source of innovative drug discove.

Under the guidance of the idea of ​​" chemical biology of traditional Chinese medicine " proposed in recent years, the team of Tu Pengfei/Zeng Kewu used cucurbitacin B as a molecular probe to " hook " from liver cancer cells to the direct target IGF2BP

Pr.

Paper link : https://pu.

About the Author

Tu Pengfei, professor, doctoral supervisor, recipient of the National Fund for Distinguished Young Scholars and the first batch of Qihuang Schola.

Zeng Kewu, researcher, doctoral tutor, was selected into the high-level talent plan of the Ministry of Educati.

Contributed by: State Key Laboratory of Natural and Biomimetic Drugs , School of Pharmacy, Peking University

Modern Research Center of Traditional Chinese Medicine, Peking University