Ubiquity binding protein: study of the bio-chemical properties of Bam protein.

Reproductive cells are the only cell types in the organism that can transmit genetic information to the next generation.
the study of reproductive cell development regulation has always been one of the core directions of developmental biology.
fate of cells caused by asymmetric division (self-renewal and differentiation) of reproductive stem cells is a key link in the development of reproductive cells and the steady state maintenance of their genealogy.
ovarian reproductive stem cells in fruit flies provide an ideal model for the study of the in vivo mechanism that determines the fate of reproductive stem cells.
the asymmetric division of fruit fly reproductive stem cells is regulated by a series of endo-and-external factors.
, the Bam protein encoded by the famous bag of marbles (bam) gene in fruit flies is a key factor in the fate of differentiation during asymmetric division of reproductive stem cells.
the past 30 years, the genetic, evolutionary and regulatory characteristics of bam gene have been widely studied in the field, but the bio-chemical properties of bam protein, its product, have remained a mystery.
The research team of Chen Dahua and Sun Qinse, of the Institute of Zoology of the Chinese Academy of Sciences, found that Bam protein is a ubirin binding protein that forms a functional complex with the de-ubiline enzyme Otu, regulating the ubibination levels of the cell cycle protein Cyclin A, thereby affecting the protein stability of Cyclin A.
study was published online May 8 in the Proceedings of the National Academy of Sciences (PNAS) under the title Bam-dependent deubiquitinase complex can disrupt germline stem cell maintenance by targeting cyclin A.
the study was supported by the National Fund Committee, the Ministry of Science and Technology and the Chinese Academy of Sciences.
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