Unexpectedly, "fat" is actually good for improving type 2 diabetes

Type 2 diabetes is a major public health problem, affecting nearly 10% of the global population
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Type 2 diabetes is caused by dysfunction of the pancreatic beta cells responsible for insulin secretion
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When fat helps beta cells

To distinguish between the effects of fat and sugar, the scientists exposed cells to excess sugar and fat, and then combined the two
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The toxicity of sugar was first demonstrated: cells exposed to high sugar levels secreted far less insulin than normal
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 "When cells are exposed to too much sugar and too much fat at the same time, they store fat in droplets to herald less prosperous times," said a researcher in the Department of Cell Physiology and Metabolism at the University School of Medicine, who said Lucie Oberhauser, first author of the work explained
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Basic uses of fat

By further analyzing the changes in the cells, the team realized that the fat droplets were not stored statically, but rather a dynamic cycle of storage and mobilization
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Scientists are now trying to determine the mechanism by which the released fat stimulates insulin secretion, hoping to discover a way to delay the onset of diabetes

Magazine

Diabetologia

DOI

10.