University of Pennsylvania discovers more genetic markers for hereditary testicular cancer

A meta-analysis of nearly 200,000 men showed that there are 22 new genetic loci that may be susceptible to hereditary testicular germ cell tumors (TGCT)-the number of areas known to be associated with cancer has increased by 40%

This multi-institutional meta-analysis was conducted by researchers from the International Testicular Cancer Alliance (TECAC), and was conducted by Katherine L.

In 2017, TECAC reported another 12 sites

Nathanson said: "This latest set of gene mapping increases our understanding of the genetic drivers of testicular cancer because we want to improve the screening of men who may be at high risk

Germ cell tumors account for 95% of testicular cancer cases

Genome-wide Association Studies (GWAS) were more successful, and found common variants associated with disease risk

In the latest study, TECAC researchers analyzed the genetic data of 10,156 testicular germ cell tumors and 179,683 controls.

This study found 22 new loci

In addition to the statistical significance of the new locus, the study also demonstrated two biological pathways related to disease susceptibility, namely male germ cell development and chromosome segregation during cell division

The author wrote: "Our findings further understand the genetic structure of TGCT, enhance the understanding of the developmental biology of male germ cells, and highlight the biological pathways that are particularly important for TGCT

Next, the researchers will begin to further investigate the increase in TGCT cases observed in Latino men and whether the genetic variants observed in most white men are also present in this population