echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > "Unlimited cancer types" continued remission for more than 4 years!

    "Unlimited cancer types" continued remission for more than 4 years!

    • Last Update: 2021-06-19
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    In recent years, a major advancement in cancer precision medicine has been the "cancer-free" therapy.


    In tropomyosin receptor kinase (TRK) fusion tumors, the NTRK gene is fused with an unrelated gene, resulting in the production of mutated TRK protein


    Nearly 3 years after its approval, the long-term efficacy data of larotrectinib once again proved the benefits of this drug "without limitation of cancer types"! A number of studies were presented at this year's American Society of Clinical Oncology (ASCO) annual meeting, including aggregated data on patients with 21 cancer types, as well as long-term data analysis for lung cancer and central nervous system (CNS) tumors


    It is worth noting that the listing application of larotrectinib in China has also been included in the proposed priority review list by the Center for Drug Evaluation (CDE) of the China National Medical Products Administration for the treatment of adult and pediatric patients with solid tumors carrying NTRK fusion genes


    Data collection of 21 cancer types: sustained remission for more than 4 years, 77% survived 3 years!

    Data collection of 21 cancer types: sustained remission for more than 4 years, 77% survived 3 years!

    This is a comprehensive analysis of long-term follow-up data from 3 clinical trials


    turn out:

    • 75% of patients achieved objective remission (tumor volume reduction reached the predetermined value and can maintain the minimum time limit), including 45 cases (22%) complete remission, 109 cases (53%) partial remission; 33 cases (16%) disease Stable, disease progression in 13 cases (6%)


      These results emphasize the importance of detecting NTRK gene fusion in cancer patients, because most TRK fusion cancer patients treated with larotrectinib have long-term clinical benefits and no new safety signals have been discovered


      Advanced lung cancer: median overall survival is more than 3 years, 73% achieve objective remission

      Advanced lung cancer: median overall survival is more than 3 years, 73% achieve objective remission

      As of July 20, 2020, the research team has aggregated data from 20 TRK fusion-positive lung cancer patients with a median age of 48.


      turn out:

      • Among the 15 evaluable patients, 73% of patients achieved objective remission, 1 complete remission, 10 partial remission; 3 stable disease and 1 disease progression


        Larotrectinib has high activity, rapid and durable remission, prolonged survival benefit and good long-term safety characteristics in advanced lung cancer patients carrying NTRK gene fusion


        CNS tumor patients: The median progression-free survival period is 18.


        CNS tumor patients: The median progression-free survival period is 18.


        It was found that after receiving larotrectinib treatment:

        • The objective response rate for all patients was 30%: 3 pediatric patients had complete remission, 7 had partial remission (2 cases to be confirmed); 20 had stable disease (including 15 patients> 6 months), and 3 had disease progression


          In patients with TRK fusion-positive central nervous system tumors, larotrectinib showed rapid and durable remission, high disease control rate and good safety characteristics


          Reference materials:

          Reference materials:

          [1] Efficacy and safety of larotrectinib in adult and pediatric patients with tropomyosin receptor kinase (TRK) fusion-positive primary central nervous system tumors.


          [1] Efficacy and safety of larotrectinib in adult and pediatric patients with tropomyosin receptor kinase (TRK) fusion-positive primary central nervous system tumors.


          [2] Long-term efficacy and safety of larotrectinib in an integrated dataset of patients with TRK fusion cancer.
          Retrieved June 8, 2021, from https://meetinglibrary.
          asco.
          org/record/195782/abstract

          [3] Long-term efficacy and safety of larotrectinib in patients with TRK fusion-positive lung cancer.
          Retrieved June 8, 2021, from https://meetinglibrary.
          asco.
          org/record/200553/abstract

          [3] Long-term efficacy and safety of larotrectinib in patients with TRK fusion-positive lung cancer.
          Retrieved June 8, 2021, from https://meetinglibrary.
          asco.
          org/record/200553/abstract
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.