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Unraveling Chemokine and Chemokine Receptor Expression Patterns Using Genetically Engineered Mice

 Last Update: 2020-12-05
 Source: Internet
 Author: User

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Over the past 25 years, genetically engineered mouse models have become an integral and invaluable research tool to developour understanding of mammalian physiology and pathology. This unit describes methods for generating transgenic mice, focusingon reporter animals relevant to chemokine receptor and ligand expression. Specifically, we describe the use of bacterial artificialchromosome (BAC) engineering and embryonic stem cell manipulation to generate “
knock in
” and transgenic mice.

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