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Chiral crown ethers are known to include stereoselectively compounds containing primary amino groups. This principle has successfully been applied in liquid chromatography (LC) using crown ether-based stationary phases (
1
–
10
). Kuhn et al. (
11
) transferred this basic principle to capillary electrophoresis (CE) using (+)−18-crown-6-tetracarboxylic acid (Fig. 1 ) as a chiral selector added to the electrolyte for the chiral separation of amino acids. This crown ether was shown to be applicable also to the chiral separation of dipeptides (
12
,
13
) (Fig. 2 ), sympathomimetics (
14
) (Fig. 3 ), and various other drugs containing primary amino groups (
15
) by CE.
