Use of Transcriptomic Data to Support Organelle Proteomic Analysis
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Last Update: 2020-12-29
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Source: Internet
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Author: User
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Genome-wide transcriptional profiling provides a rich source of data for the validationand annotation of organelle proteomic data. Organelle biogenesis is in most cases accompaniedby upregulation of genes encoding organelle-specific proteins. Consequently,identification of genes whose expression correlates with organelle assembly leads to acandidate list that can be cross-checked with a preliminary organelle proteome. Whenproteins are found in the proteome and the corresponding genes are found to have organelleassembly-correlated expression, this greatly increases our confidence that those proteinsare true components of the organelle and not contamination. Such an approach can beused to narrow down a preliminary proteomic data set and help us to focus on a smallersub-set of proteins that are supported by transcriptomic cross-validation.
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