Using acid-sensitive drug delivery system to synergistically induce tumor cell iron death and immunogenic death

Immunotherapy can activate the systemic anti-tumor immune effect, inhibit tumor growth, metastasis and recurrence, and has shown great potential in clinical tumor treatment

Iron death is a new type of cell death caused by iron-dependent lipid peroxidation discovered in recent years

Based on the above research background, the Haijun Yu team of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences proposed a strategy to use the acid-sensitive drug delivery system to synergistically induce tumor cell iron death and immunogenic death, thereby improving the anti-tumor immune response

Research data shows that the nanoparticles encapsulating RSL-3 can be selectively enriched in tumor tissues through the EPR effect, and the application of external light can induce the immunogenic death of tumor cells, initiate anti-tumor immune responses, and induce the secretion of cytotoxic T lymphocytes.

Related research results were published in Advanced Materials on June 25, 2021.

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Figure 1.

(Contributor: Yu Haijun Research Group; Contributor: Li Tianliang)